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Identification of pig growth associated-markers using within-breed expression profiling

Research Project

Project/Area Number 24580406
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied animal science
Research InstitutionNiigata University

Principal Investigator

YAMADA Takahisa  新潟大学, 自然科学系, 教授 (40253207)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords家畜ゲノム
Outline of Final Research Achievements

We first performed detection of polymorphisms in positional functional candidates for the genes responsible for growth traits in Landrace pig breed with direct-sequencing and establishment of genotyping method. Based on association study with Landrace pig population, the D-Loop/846 SNP determining specifically mitochondrial D-Loop haplotype 4 showed a significant effect on the maternal lineage effect for the age at 100 kg. Further, the COQ3/-1623 indel polymorphism in the nuclear COQ3 gene was associated with the predicted breeding value for the age at 100 kg. In conclusion, we suggested that the two polymorphisms are useful for effective marker-assisted selection to increase of growth rate in Landrace pig breed.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (36 results)

All 2015 2014 2013 2012

All Journal Article (26 results) (of which Peer Reviewed: 16 results) Presentation (10 results) (of which Invited: 1 results)

  • [Journal Article] Genetic dissection of marbling trait through integration of mapping and expression profiling2014

    • Author(s)
      T. YAMADA
    • Journal Title

      Animal Science Journal

      Volume: 85 Pages: 349-355

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multiple marker effects of single nucleotide polymorphisms in three genes, AKIRIN2, EDG1 and RPL27A, for marbling development in Japanese Black cattle2014

    • Author(s)
      S. SUKEGAWA, T. MIYAKE, T. IBI, Y. TAKAHAGI, H. MURAKAMI, F. MORIMATSU and T. YAMADA
    • Journal Title

      Animal Science Journal

      Volume: 85 Pages: 193-197

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of novel genetic markers and evaluation of genetic structure in the Japanese population of the Japanese crested ibis2014

    • Author(s)
      K. TSUBONO, Y. TANIGUCHI, H. MATAUDA, T. YAMADA, T. SUGIYAMA, K. HOMMA, Y. KANEKO, S. YAMAGISHI and H. IWAISAKI
    • Journal Title

      Animal Science Journal

      Volume: 85 Pages: 356-364

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Estimation of variance components for carcass traits in Japanese Black cattle using 50K SNP genotype data2014

    • Author(s)
      T. WATANABE, H. MATSUDA, A. ARAKAWA, T. YAMADA, H. IWAISAKI, S. NISHIMURA and Y. SUGIMOTO
    • Journal Title

      Animal Science Journal

      Volume: 85 Pages: 1-7

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The G allele at the g.70014208A>G in the MYBPC1 gene associated with high marbling in Japanese Black cattle is at a low frequency in breeds not selected for marbling2014

    • Author(s)
      B. TONG, S. SASAKI, Y. MURAMATSU, T. OHTA, H. KOSE, T. FUJITA and T. YAMADA
    • Journal Title

      Journal of Genetics

      Volume: 93 Pages: 231-233

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of a single-nucleotide polymorphism in myosin-binding protein C, slow-type (MYBPC1) gene with marbling in Japanese Black beef cattle2014

    • Author(s)
      B. TONG, S. SASAKI, Y. MURAMATSU, T. OHTA, H. KOSE, H. YAMASHIRO, T. FUJITA and T. YAMADA
    • Journal Title

      Animal Genetics

      Volume: 45 Pages: 611-612

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The nucleotide sequences for the dopamine receptor D4 gene in the Japanese crested ibis2014

    • Author(s)
      Y. KOMATSU, M. YAMASHITA, T. YAMADA, B. TONG, T. OHTA, T. SUGIYAMA, H. YAMASHIRO, Y. KANEKO, H. NAGATA and H. IWAISAKI
    • Journal Title

      Journal of Animal Genetics

      Volume: 42 Pages: 3-9

    • NAID

      130004939784

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of single nucleotide polymorphism in IRS1 gene with growth-related trait in Japanese Black beef cattle2014

    • Author(s)
      Y. WU, B. TONG, K. WU, S. SASAKI, Y. MURAMATSU, T. OHTA, H. KOSE, T. YAMADA, D. ZHANG and G. NI
    • Journal Title

      Journal of Animal and Veterinary Advances

      Volume: 13 Pages: 37-40

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Possible association of single nucleotide polymorphism in the myosin heavy chain 1 gene with growth-related trait in Japanese Black beef cattle2014

    • Author(s)
      B. TONG, K. WU, S. SASAKI, Y. MURAMATSU, T. OHTA, H. KOSE and T. YAMADA
    • Journal Title

      Journal of Animal and Veterinary Advances

      Volume: 13 Pages: 41-44

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure and polymorphism of the major histocompatibility complex class II region in the Japanese Crested Ibis, Nipponia nippon2014

    • Author(s)
      Y. TANIGUCHI, K. MATSUMOTO, H. MATSUDA, T. YAMADA, T. SUGIYAMA, K. HOMMA, Y. KANEKO, S. YAMAGISHI and H. IWAISAKI
    • Journal Title

      PLoS One

      Volume: 9

    • NAID

      120005496634

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The assessment of genetic diversity within and among the eight subpopulations of Japanese Black cattle using 52 microsatellite markers.2013

    • Author(s)
      T. NISHIMAKI, T. IBI, Y. TANABE, Y. MIYAZAKI, N. KOBAYASHI, T. MATSUHASHI, T. AKIYAMA, E. YOSHIDA, K. IMAI, M. MATSUI, K. UEMURA, N. WATANABE, T. FUJITA, Y. SAITO, T. KOMATSU, T. YAMADA, H. MANNEN, S. SASAZAKI, T. KUNIEDA
    • Journal Title

      Animal Science Journal

      Volume: 84 Pages: 585-591

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Genome-wide SNP and STR discovery in the Japanese crested ibis and genetic diversity among founders of the Japanese population.2013

    • Author(s)
      Y. TANIGUCHI, H. MATSUDA, T. YAMADA, T. SUGIYAMA, K. HOMMA, Y. KANEKO, S. YAMAGISHI, H. IWAISAKI
    • Journal Title

      PLoS One

      Volume: 8

    • NAID

      120005324898

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Genetic diversity and structure in the Sado captive population of the Japanese crested ibis.2013

    • Author(s)
      K. URANO, K. TSUBONO, Y. TANIGUCHI, H. MATSUDA, T. YAMADA, T. SUGIYAMA, K. HOMMA, Y. KANEKO, S. YAMAGISHI, H. IWAISAKI
    • Journal Title

      Zoological Science

      Volume: 30 Pages: 432-438

    • NAID

      120005477208

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Replicated association of the single nucleotide polymorphism in PNLIP with marbling in Niigata population of Japanese Black beef cattle.2013

    • Author(s)
      H. TANOMURA, Y. MURAMATSU, T. YAMAMOTO, T. OHTA, H. KOSE, T. YAMADA
    • Journal Title

      Open Journal of Animal Sciences

      Volume: 3 Pages: 89-92

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 間接検定調査牛における脂肪交雑関連遺伝子の一塩基多型の効果の検討.2013

    • Author(s)
      佐々木整輝・伊藤智仁・荻野敦・清水一広・森田光夫・山田宜永
    • Journal Title

      北信越畜産学会報

      Volume: 106 Pages: 49-55

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] No replicated association of the c.-312A>G in EDG1 with marbling in Niigata population of Japanese Black beef cattle.2013

    • Author(s)
      B. TONG, N. FUKE, Y. HIMIZU, H. KATOU, M. HATANO, T. OHTA, H. KOSE, T. YAMADA
    • Journal Title

      Open Journal of Animal Sciences

      Volume: 3 Pages: 269-272

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] The W- and Z-linked EE0.6 sequences used for molecular sexing of captive Japanese crested ibis on Sado Island.2012

    • Author(s)
      K. KASUGA, M. HIGASHI, T. YAMADA, T. SUGIYAMA, Y. TANIGUCHI, H. IWAISAKI, K. HOMMA, Y. WAJIKI, Y. KANEKO, and S. YAMAGISHI
    • Journal Title

      Animal Science Journal

      Volume: 83 Pages: 83-87

    • Related Report
      2012 Research-status Report
  • [Journal Article] Pancreatic abnormality at a young age in spontaneously diabetic Torii (SDT) rats.2012

    • Author(s)
      T. OHTA, M. SHINOHARA, T. YAMAMOTO, amd T. YAMADA
    • Journal Title

      Journal of Animal and Veterinary Advances

      Volume: 11 Pages: 1322-1326

    • Related Report
      2012 Research-status Report
  • [Journal Article] Association of single nucleotide polymorphism in pancreatic lipase gene with growth-related traits in Japanese Black beef cattle.2012

    • Author(s)
      H. TANOMURA, Y. MURAMATSU, T. YAMAMOTO, T. OHTA, H. KOSE, and T. YAMADA
    • Journal Title

      Journal of Animal and Veterinary Advances

      Volume: 11 Pages: 1346-1349

    • Related Report
      2012 Research-status Report
  • [Journal Article] Distribution of allele frequency at PNLIP rs41648172 between Japanese Black and four other cattle breeds with differing historical selection for marbling.2012

    • Author(s)
      H. TANOMURA, Y. MURAMATSU, T. YAMAMOTO, T. OHTA, H. KOSE, and T. YAMADA
    • Journal Title

      Journal of Animal and Veterinary Advances

      Volume: 11 Pages: 1350-1352

    • Related Report
      2012 Research-status Report
  • [Journal Article] Inhibition of postprandial hyperglycemia prevents the incidence of diabetes in spontaneously diabetic Torii (SDT) rats.2012

    • Author(s)
      T. OHTA, K. MIYAJIMA, M. SHINOHARA, T. YAMAMOTO, and T. YAMADA
    • Journal Title

      Journal of Animal and Veterinary Advances

      Volume: 11 Pages: 1583-1587

    • Related Report
      2012 Research-status Report
  • [Journal Article] Effect of phlorizin on metabolic abnormalities in spontaneously diabetic Torii (SDT) rats.2012

    • Author(s)
      T. OHTA, H. MORINAGA, T. YAMAMOTO, and T. YAMADA
    • Journal Title

      Open Journal of Animal Sciences

      Volume: 2 Pages: 113-118

    • Related Report
      2012 Research-status Report
  • [Journal Article] Polymorphism in promoter region of CDC10 gene showing marbling-associated expression changes.2012

    • Author(s)
      B. TONG, Y. MURAMATSU, T. YAMAMOTO, H. TANOMURA, T. OHTA, H. KOSE, T. SUGIYAMA, and T. YAMADA
    • Journal Title

      Journal of Animal and Veterinary Advances

      Volume: 11 Pages: 1930-1933

    • Related Report
      2012 Research-status Report
  • [Journal Article] Useful marker around TRDN gene showing marbling-associated expression changes.2012

    • Author(s)
      B. TONG, Y. MURAMATSU, T. YAMAMOTO, H. TANOMURA, T. OHTA, H. KOSE, T. SUGIYAMA, and T. YAMADA
    • Journal Title

      Journal of Animal and Veterinary Advances

      Volume: 11 Pages: 2792-2795

    • Related Report
      2012 Research-status Report
  • [Journal Article] Preliminary association study of SNPs in MFN2 gene showing marbling-associated expression changes.2012

    • Author(s)
      B. TONG, Y. MURAMATSU, T. YAMAMOTO, H. TANOMURA, T. OHTA, H. KOSE, T. SUGIYAMA, and T. YAMADA
    • Journal Title

      Journal of Animal and Veterinary Advances

      Volume: 11 Pages: 2796-2800

    • Related Report
      2012 Research-status Report
  • [Journal Article] Single diabetic QTL derived from OLETF rat is a sufficient agent for severe diabetic phenotype in combination with leptin-signaling deficiency.2012

    • Author(s)
      H. KOSE, T. YAMADA, and K. MATSUMOTO
    • Journal Title

      Experimental Diabetes Research

      Volume: 858121 Pages: 858121-858121

    • Related Report
      2012 Research-status Report
  • [Presentation] ランドレース種における増体原因遺伝子の位置的機能的候補のウエスタンブロット解析および多型解析2015

    • Author(s)
      山下舞・助川慎・小松優太・勝田尚樹・山田宜永・藤村達也・森松文毅
    • Organizer
      日本畜産学会第119回大会
    • Place of Presentation
      宇都宮市
    • Year and Date
      2015-03-28 – 2015-03-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] ランドレース種における系統造成を目的とした増体関連マーカーの開発2014

    • Author(s)
      山下舞・助川慎・藤村達也・森松文毅・山田宜永
    • Organizer
      第63回北信越畜産学会大会
    • Place of Presentation
      福井市
    • Year and Date
      2014-11-20 – 2014-11-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] ランドレース種における増体原因遺伝子候補の多型と増体形質との相関解析2013

    • Author(s)
      小松優太・助川慎・三宅武・高萩陽一・森松文毅・山田宜永
    • Organizer
      第51回北信越畜産学会新潟県分会
    • Place of Presentation
      新潟市
    • Related Report
      2013 Research-status Report
  • [Presentation] ランドレース種における増体関連発現パターンをもつ遺伝子の同定および増体原因遺伝子の位置的機能的候補の同定2013

    • Author(s)
      山下舞・助川慎・高萩陽一・森松文毅・山田宜永
    • Organizer
      第51回北信越畜産学会新潟県分会
    • Place of Presentation
      新潟市
    • Related Report
      2013 Research-status Report
  • [Presentation] 哺乳動物における量的形質の遺伝的解剖に関する研究2013

    • Author(s)
      山田宜永
    • Organizer
      日本畜産学会第116回大会
    • Place of Presentation
      広島市
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] MYBPC1のg.70014208G>A SNPとウシ脂肪交雑の相関解析2013

    • Author(s)
      Tong Bin・藤田達男・三宅武・山田宜永
    • Organizer
      日本畜産学会第116回大会
    • Place of Presentation
      広島市
    • Related Report
      2013 Research-status Report
  • [Presentation] 豚ランドレース種の増体原因遺伝子に関する遺伝子プロファイリングと位置的機能的候補の選定2013

    • Author(s)
      助川慎・山下舞・藤村達也・森松文毅・山田宜永
    • Organizer
      日本畜産学会第117回大会
    • Place of Presentation
      新潟市
    • Related Report
      2013 Research-status Report
  • [Presentation] ランドレース種における増体原因遺伝子候補の多型と増体形質との相関解析2013

    • Author(s)
      小松優太・山下舞・助川慎・三宅武・高萩陽一・森松文毅・山田宜永
    • Organizer
      第62回北信越畜産学会大会
    • Place of Presentation
      金沢市
    • Related Report
      2013 Research-status Report
  • [Presentation] ランドレース種における増体原因遺伝子候補の多型と増体形質との相関解析.2013

    • Author(s)
      小松優太・助川慎・高萩陽一・森松文毅・山田宜永
    • Organizer
      第51回北信越畜産学会新潟県分会
    • Place of Presentation
      新潟大学
    • Related Report
      2012 Research-status Report
  • [Presentation] ランドレース種における増体関連発現パターンをもつ遺伝子の同定および増体原因遺伝子の位置的機能的候補の選定2013

    • Author(s)
      山下舞・助川慎・三宅武・高萩陽一・森松文毅・山田宜永
    • Organizer
      第51回北信越畜産学会新潟県分会
    • Place of Presentation
      新潟大学
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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