Regulation of FBXO22 expression in skeletal muscle by nutritional and physiological conditions

Research Project

Project/Area Number	24580414
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Applied animal science
Research Institution	National Agriculture and Food Research Organization
Principal Investigator	NAKASHIMA Kazuki 独立行政法人農業・食品産業技術総合研究機構, 畜産草地研究所家畜生理栄養研究領域, 主任研究員 (70370583)
Project Period (FY)	2012-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000) Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000) Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	ニワトリ / タンパク質分解 / FBXO22 / アトロジン－１ / 骨格筋 / アトロジン－1 / アトロジン-1
Outline of Final Research Achievements	Atrogin-1, a muscle-specific E3 ubiquitin ligase, is regulated by nutritional and physiological conditions that result in muscle atrophy. FBOX22 is also an E3 ubiquitin ligase, but regulation of FBOX22 expression by nutritional and physiological conditions is largely unknown. In skeletal muscle of chicken, atrogin-1 and FBXO22 was regulated by nutritional conditions, and expression of FBXO22 and atrogin-1 was also regulated by various hormones. In particular, expression of FBXO22 and atrogin-1 was regulated by glucocorticoid via glucocorticoid receptor. These results indicate that expression of FBXO22 and atrogin-1 is differently regulated by nutritional and physiological conditions in chick skeletal muscle.