| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Ynamides are useful synthons because they exhibit high reactivity toward electrophiles and can be adapted to asymmetric reactions if ynamides are chiral. Therefore, I have developed the iodocyclization of ynamides: for examples, benzofuran synthesis was achieved within three seconds in milder reaction conditions than using normal alkynes. In addition, 6-endo type iodocyclization of homopropargylic hydrazides as substrates proceeded by using ynamides to afford dihydropyridazines. Furthermore, tandem dearomative iodocyclization/ Diels-Alder reaction and polyene cyclization using chiral ynamides were demonstrated in diastereoselective manner to obtain optically active spiro rings and tricyclic skeletons.
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