Energy regulation by dietary gut microbial metabolites via short-chain fatty acids receptors
Project/Area Number |
24590077
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Biological pharmacy
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Research Institution | Tokyo University of Agriculture and Technology (2013-2014) Kyoto University (2012) |
Principal Investigator |
IKUO Kimura 東京農工大学, (連合)農学研究科(研究院), 准教授 (80433689)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | 脂肪酸受容体 / 脂肪組織 / ノックアウトマウス / GPCR / 短鎖脂肪酸 / 腸内細菌 |
Outline of Final Research Achievements |
We report that short-chain fatty acid receptor GPR43 is abundantly expressed in adipose tissues and GPR43-deficient mice are obese on a normal diet, whereas mice overexpressing GPR43 specifically in adipose tissue remain lean. We further report that short-chain fatty acid-mediated activation of GPR43 suppresses insulin signalling in adipocytes, which inhibits fat accumulation in adipose tissue and promotes the metabolism of unincorporated lipids and glucose in other tissues. Recently, we confirmed that GPR43 was expressed in macrophage in adipose tissue inflammation.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43.2013
Author(s)
Kimura I, Ozawa K, Inoue D, Imamura T, Kimura K, Maeda T, Terasawa K, Kashihara D, Hirano K, Tani T, Takahashi T, Miyauchi S, Shioi G, Inoue H, Tsujimoto G.
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Journal Title
Nat Commun.
Volume: 4
Issue: 1
Pages: 1829-1829
DOI
NAID
Related Report
Peer Reviewed
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