Dvelopment of novel anti-obesity agents targeting cell-surface F1F0-ATP synthase
| Project/Area Number |
24590081
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | The University of Tokushima |
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Principal Investigator |
ARAKAKI Naokatu 徳島大学, ヘルスバイオサイエンス研究部, 准教授 (60151148)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAZAKI Tetsuo 徳島大学, 大学院ヘルスバイオサイエンス研究部, 教授 (90330208)
NEMOTO Hisao 徳島大学, 大学院ヘルスバイオサイエンス研究部, 准教授 (30208293)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | Ｆ１Ｆｏ-ＡＴＰ合成酵素 / 脂肪細胞 / 細胞内中性脂肪 / 抗肥満薬 / ＡＴＰ / ＡＴＰ受容体 / シグナル伝達 / ミトコンドリア / 国際情報交換 |
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| Outline of Final Research Achievements |
Cell-surface F1F0-ATP synthase plays a role on intracellular triacylglycerol (TG) accumulation in adipocytes. Here we show that cell-surface F1F0-ATP synthase on adipocytes is functional in extracellular ATP production and that the extracellular ATP produced contributes, at least in part, to the cell-surface F1F0-ATP synthase-mediated intracellular triacylglycerol (TG) accumulation in adipocytes through P2Y1 receptor. We synthesized water-soluble resveratrol and piceatannol which are F1F0-ATP synthase inhibitors) and found that these compounds significantly lowered abdominal visceral adipose tissue in diet-induced obese mice.
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Report
(4 results)
Research Products
(10 results)
