Development of antiepileptic compounds for intractable epilepsy based on ketone bodies
| Project/Area Number |
24590114
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Okayama University |
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Principal Investigator |
INOUE TSUYOSHI 岡山大学, 医歯(薬)学総合研究科, 准教授 (40370134)
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| Co-Investigator(Renkei-kenkyūsha) |
MORIYAMA Yoshinori 岡山大学, 大学院医歯薬学総合研究科, 教授 (10150658)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 難治性てんかん / ケトン食療法 / グルタミン酸作動性シナプス / ケトン体 / 乳酸 / スライスパッチクランプ法 / 代謝物 / 構造活性相関 / 膜電位 / ケトン食 |
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| Outline of Final Research Achievements |
It is known that ketogenic diet treatment is effective for patients with drug-resistant epilepsy. In this study, we focused on metabolic changes induced by ketogenic diets (increases in ketone bodies and decreases in glucose), examined the antiepileptic mechanisms, and explored the mechanism-based antiepileptic compounds. By changing the chemical structure of a ketone body, we found a compound that suppresses excitatory synaptic transmission and epileptiform discharges in vivo. We also found a new mechanism of neural inhibition and antiepileptic action induced by ketogenic diets, and identified the mechanism-based antiepileptic compound.
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Report
(4 results)
Research Products
(10 results)
