| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
To develop nucleoside derivatives applicable to introduce an oligonucleotide which can be used as nucleic acid medicine, design and synthesis of new nucleosides were investigated. We designed the following three nucleoside derivatives: 1) dihydropyranonucleoside, 2) L-threopentofuranosyl nucleoside, 3) 3’-deoxy-4’-thionucleoside. L-Threopentofuranosyl nucleoside was further converted to the corresponding nucleoside phosphonate derivative. All the nucleoside derivatives obtained were evaluated their antiviral activity including HIV.
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