Development of a method for assessing human exposure to cross-boundary air pollutions by polycyclic aromatic sulfur heterocyclic compounds as chemical markers
Project/Area Number |
24590160
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Environmental pharmacy
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Research Institution | Kanazawa University |
Principal Investigator |
TORIBA Akira 金沢大学, 薬学系, 准教授 (50313680)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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Keywords | バイオマーカー / 石炭燃焼 / 越境汚染 / 曝露評価 / アジア |
Outline of Final Research Achievements |
Polycyclic aromatic sulfur heterocyclic compounds (PASHs) are organic pollutants from coal combustion, which has become a major source of air pollution in China and are estimated to be a cross-boundary pollutant such as Asian dust. Urinary metabolites of PASHs as a biomarker for coal burning exposure were examined in this study. Dibenzothiophene (DBT) was predicted to have high exposures to humans in the tested PASH candidates. DBT metabolites from DBT administered rat urine were successfully identified and its metabolic pathway was elucidated. The analysis of human urine samples suggested the possibility of the metabolite excretion. It is concluded that the identified major metabolite is a convincing biomarker candidate for the biomarker of exposure to coal-burning smoke.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] Air Pollution with Particulate Matter and Mutagens: Relevance of Asian Dust to Mutagenicity of Airborne Particles in Japan2014
Author(s)
Watanabe, T., Hasei, T., Ikemori, F., Funasaka, K., Toriba, A., Hayakawa, K., Arashidani, K., Inaba, Y., Sera, N., Deguchi, Y., Seiyama, T., Yamaguchi, T.,
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Journal Title
Genes and Environment
Volume: 36
Issue: 3
Pages: 120-136
DOI
NAID
ISSN
1880-7046, 1880-7062
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Factors affecting atmospheric 1-, 2-nitropyrenes and 2-nitrofluoranthene in winter at Noto peninsula, a remote background site, Japan2014
Author(s)
N. Tang, K. Sato, T. Tokuda, M. Tatematsu, H. Hama, C. Suematsu, T. Kameda, A. Toriba, K. Hayakawa
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Journal Title
Chemosphere
Volume: 107
Pages: 324-330
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Inhalation and dietary exposure to Dechlorane Plus and polybrominated diphenyl ethers in Osaka, Japan.2014
Author(s)
Kakimoto, K., Nagayoshi, H., Takagi, S., Akutsu, K., Konishi, Y., Kajimura, K., Hayakawa, K., Toriba, A.
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Journal Title
Ecotoxicology and Environmental Safety
Volume: 99
Pages: 69-73
DOI
Related Report
Peer Reviewed
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[Presentation] Chlorinated Polycyclic Aromatic Hydrocarbons in Air Particulates in North-East Asia.2014
Author(s)
Kakimoto, K., Nagayoshi, H., Takagi, S., Konishi1, Y., Kajimura, K., Ohura, T., Hayakawa, K., Toriba, A.
Organizer
International Conference of Asian Environmental Chemistry 2014
Place of Presentation
Bangkok, Thailand
Year and Date
2014-11-24 – 2014-11-26
Related Report
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