| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
The human blood-brain barrier cells have been shown to retain the proton-coupled organic cation antiporter, which is involved in efficient blood-to-brain transport of oxycodone. Further, tramadol, a weak opioid, was also actively transported into the brain across the blood-brain barrier by the proton-coupled organic cation antiporter. Both apomorphine enantiomers were efficiently transported into the brain with similar kinetic parameters. The proton-coupled organic cation antiporter is mediated efficient brain transport of apomorphine and it should be relevant to the rapid onset of pharmacological action of this rescue drug.
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