The analysis of congenital anomalies of caudal body formation
| Project/Area Number |
24590235
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
Suzuki Kentaro 和歌山県立医科大学, 先端医学研究所, 講師 (20404345)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | sirenomelia / 体幹後部形成 / Isl1 / Bmp4 / Bmpシグナル / プロジェニター / マーメイドシンドローム / Bmp / 体幹後部 / 泌尿生殖器 / Sirenomelia |
|---|
| Outline of Final Research Achievements |
Mermaid syndrome is a developmental malformation of the caudal body characterized by leg fusion and associated anomalies of pelvic/urogenital organs including bladder, kidney, rectum and external genitalia. Despite the many clinical studies of mermaid syndrome in humans, little is known about the pathogenic developmental mechanisms that cause the complex array of phenotypes observed. Isl1Cre;Bmp4flox/flox conditional mutant mice displayed mermaid-like phenotypes including hindlimb fusion and pelvic/urogenital organ dysgenesis. Genetic lineage analyses indicated that Isl1-expressing cells contribute to both the aPCM (anterior Peri-Cloacal Mesenchyme) and the hindlimb bud. Furthermore, we show Bmp signaling is essential for the aPCM formation.
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Report
(5 results)
Research Products
(16 results)
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[Journal Article] Disruption of the temporally regulated cloaca endodermal β-catenin signaling causes anorectal malformations2014
Author(s)
Miyagawa S, Harada M, Matsumaru D, Tanaka K, Inoue C, Nakahara C, Haraguchi R, Matsushita S, Suzuki K, Nakagata N, Ng RC, Akita K, Lui VC, Yamada G.
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Journal Title
Cell Death Differ.
Volume: 21
Issue: 6
Pages: 990-997
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] β-Catenin signaling regulates Foxa2 expression during endometrial hyperplasia formation2013
Author(s)
Villacorte M, Suzuki K, Hirasawa A, Ohkawa Y, Suyama M, Maruyama T, Aoki D, Ogino Y, Miyagawa S, Terabayashi T, Tomooka Y, Nakagata N, Yamada G
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Journal Title
Oncogene
Volume: 32
Issue: 29
Pages: 3477-3482
DOI
Related Report
Peer Reviewed
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