Roles of tissue-fibrinolytic system in bone/cartilage regeneration
| Project/Area Number |
24590289
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
General physiology
|
|---|
| Research Institution | Kinki University |
|---|
Principal Investigator |
KAJI Hiroshi 近畿大学, 医学部, 教授 (90346255)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KAWAO Naoyuki 近畿大学, 医学部, 講師 (70388510)
岡田 清孝 近畿大学, 医学部, 講師 (20185432)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 骨・軟骨再生 / 骨修復 / 線溶 / 骨形成 / プラスミノゲン / プラスミノゲンアクチベーター / PAI-1 / 血管形成 / 骨再生 / 骨芽細胞 / 線溶系 / 骨代謝 / 糖尿病 |
|---|
| Outline of Final Research Achievements |
Previous evidence suggested that tissue-fibrinolytic system and subsequent proteolytic system and growth factor induction play important roles in tissue repair. We therefore investigated the roles of tissue-fibrinolytic system in bone repair and regeneration in this study. We established the model to evaluate the process of bone repair and regeneration by making a bone defect in mouse femorae. We demonstrated that plasminogen is crucial for bone repair process using plasminogen-deficient mice. Moreover, tissue-type plasminogen activator (tPA) is involved in bone repair using tPA-deficient mice. In that study, we showed that tPA enhances the proliferation of osteoblasts through Annexin 2 and MAP kinase.
|
Report
(4 results)
Research Products
(13 results)
