Chronic stress and atopic dermatitis:Research on preventive and therapeutic effects of odorant and its mechanism

• Project/Area Number: 24590299
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Environmental physiology (including Physical medicine and Nutritional physiology)
• Research Institution: Tottori University
• Principal Investigator: WATANABE TATSUO 鳥取大学, 医学部, 教授 (60182929)
• Co-Investigator(Kenkyū-buntansha): MIYOSHI Michio 鳥取大学, 医学部, 助教 (20093627) ; KOBA Satoshi 鳥取大学, 医学部, 講師 (40565743) ; UMEKITA Yoshihisa 鳥取大学, 医学部, 教授 (80244226) ; 庄盛 浩平 鳥取大学, 医学部, 講師 (60314572)
• Co-Investigator(Renkei-kenkyūsha): YAMADA Nanako 鳥取大学, 医学部附属病院, 准教授 (10304213)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
• Keywords: アトピー性皮膚炎 / 香料 / ストレス / 皮膚バリア / 角質水分量 / ピクリルクロライド

Outline of Final Research Achievements

We investigated whether inhalation of green odor or rose odor cures and/or prevents the atopic dermatitis (AD) induced in mice and human. The green odor had no effect on the AD in mice. On the other hand, the AD patient inhaling the rose odor had more skin hydration than those without the odor. The present results suggest that rose odor has a therapeutic effect on AD in human.

Research Products

• [Journal Article] Central command dysfunction in rats with heart failure is mediated by brain oxidative stress and normalised by exercise training. (2014)
  • Author(s): Koba, S., Hisatome, I. and Watanabe, T.
  • Journal Title: Journal of Physiology (London) Volume: 592 Issue: 17 Pages: 3917-3931
  • DOI: 10.1113/jphysiol.2014.272377
  • Peer Reviewed / Open Access
• [Journal Article] Running training attenuates blood pressure and norepinephrine responses to immobilization stress in spontaneously hypertensive rats (2013)
  • Author(s): Miyoshi, M. & Watanabe T.
  • Journal Title: The Journal of Physical Fitness and Sports Medicine Volume: 2 Issue: 3 Pages: 365-372
  • DOI: 10.7600/jpfsm.2.365
  • NAID: 10031179363
  • ISSN: 2186-8123, 2186-8131
  • Peer Reviewed
• [Journal Article] Oxidative stress exaggerates skeletal muscle contraction-evoked reflex sympathoexcitation in rats with hypertension induced by angiotensin II. American Journal of Physiology (2013)
  • Author(s): Koba, S., Watanabe, R., Kano, N. and Watanabe, T
  • Journal Title: Heart and Circulatory Physiology Volume: 304 Issue: 1 Pages: H142-H153
  • DOI: 10.1152/ajpheart.00423.2012
  • Peer Reviewed
• [Journal Article] Effect of "rose essential oil" inhalation on stress-induced skin-barrier disruption in rats and humans (2012)
  • Author(s): Fukada M., et al
  • Journal Title: Chemical Senses Volume: 37 Issue: 4 Pages: 347-356
  • DOI: 10.1093/chemse/bjr108
  • Peer Reviewed
• [Journal Article] Exercise pressor reflex function in female rats fluctuates with the estrous cycle. (2012)
  • Author(s): Koba, S., Yoshinaga, K., Fujita, S., Miyoshi, M. and Watanabe, T.
  • Journal Title: Journal of Applied Physiology Volume: 113(5) Issue: 5 Pages: 719-726
  • DOI: 10.1152/japplphysiol.00396.2012
  • Peer Reviewed
• [Journal Article] Evaluation of an e-learning distance education system in the graduate school of medical sciences of Tottori University (2012)
  • Author(s): Houri, D., Watanabe, T., Hayashi, K. & Kurozawa, Y.
  • Journal Title: Yonago Acta Medica Volume: 55 Pages: 69-73
  • NAID: 120005032394
  • Peer Reviewed
• [Presentation] ストレスによる甘味・うま味受容体発現抑制の機序～グルココルチコイドの関与について～ (2015)
  • Author(s): 渡邊達生、小川修史、領家和男
  • Organizer: 第92回日本生理学会大会
  • Place of Presentation: 神戸国際会議場・展示場（神戸市）
  • Year and Date: 2015-03-23
• [Presentation] ホワイトノイズ音暴露時のラット心拍数調節における中脳中心灰白質の役割 (2014)
  • Author(s): 木場智史、井上崚、渡邊達生
  • Organizer: 第66回日本生理学会中国四国地方会
  • Place of Presentation: 情報通信交流館 e-とぴあ・かがわ（髙松市）
  • Year and Date: 2014-11-02
• [Presentation] 心不全ラットにおける恐怖時徐脈応答の異常 (2014)
  • Author(s): 木場智史、久留一郎、渡邊達生
  • Organizer: 日本生理学会大会
  • Place of Presentation: 鹿児島大学 郡元キャンパス（鹿児島市）
• [Presentation] Tiron, a superoxide scavenger, suppresses fictive locomotionevoked sympathoexcitation in rats with heart failure (2013)
  • Author(s): Koba, S., Inoue, Y., Hosatome, I., & Watanabe, T.
  • Organizer: Experimental Biology
  • Place of Presentation: Boston Convention & Exposition Center (Boston, USA)
• [Presentation] バラの香りを吸入するとストレスによる皮膚バリア障害が抑制される ~ラットとヒトを用いた検討~ (2013)
  • Author(s): 弓岡英里、深田美香、渡邊達生
  • Organizer: 日本生理学会大会
  • Place of Presentation: タワーホール船堀（東京都）
• [Presentation] 心筋梗塞ラットの運動トレーニングは中枢性交感神経賦活応答を抑制する (2012)
  • Author(s): 木場智史、井上裕美子、久留一郎、渡邊達生
  • Organizer: 日本生理学会中国四国地方会
  • Place of Presentation: 高知市文化プラザ かるぽーと（高知市）
• [Remarks] 統合生理学分野 I 統合生理学分野
  • URL: http://www.med.tottori-u.ac.jp/intgphys/6005.html