| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
It has been suggested that reactive oxygen species are involved in the mechanism of retinal neuronal cell death induced by retinal degenerative diseases, such as retinitis pigmentosa and glaucoma. Minor iron elements, such as iron, are involved in generation of reactive oxygen species. In the present study, I demonstrated that iron chelators are protective against retinal degeneration in the mouse model of retinitis pigmentosa, and that induced by intravitreal N-methyl-D-aspartic acid injection.
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