| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Outline of Final Research Achievements |
We examined histological and immunohistochemical changes of synovium before and after DMARDs or biologics (Bio) treatment for rheumatoid arthritis (RA). Synovial tissues were obtained from 52 RA patients. Twenty of them took DMARDs before Bio. In responder of Bio, the number of synovial cells, high endothelial venules and inflammatory cells decreased. In addition, the number of positive cells of MMP-3, TNFα, CD68 and CD34 decreased, too. On the other hand, synovial inflammation worsened in non-responder of Bio and immunohistochemical findings showed opposite results to responder. The inflammatory and immunohistochemical scores decreased more massive after treatment by Bio than DMARDs. Especially, the effect of the biologics was massive in non-responder of DMARDs. The results suggest that Bio may stop the vicious circle in responder by decreasing the number of TNFα positive cells and have stronger anti-inflammatory effects especially in non-responder of DMARDs.
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