Role of CD146, a cell adhesion molecule, in early diagnosis and pathogenesis of malignant pleural mesothelioma
| Project/Area Number |
24590437
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
SATO AYUKO 兵庫医科大学, 医学部, 講師 (20419823)
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| Co-Investigator(Kenkyū-buntansha) |
TSUJIMURA Tohru 兵庫医科大学, 医学部, 教授 (20227408)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 悪性胸膜中皮腫 / CD146 / 早期診断 / 予後因子 |
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| Outline of Final Research Achievements |
CD146, a cell adhesion molecule, was expressed in 85% of malignant pleural mesothelioma but not in reactive mesothelium. The level of soluble form of CD146 was significantly higher in pleural effusions of malignant pleural mesothelioma than those of benign diseases such as pleuritis. In addition, the postoperative overall survival of patients with high expression of CD146 in malignant pleural mesothelioma was significantly shorter than that with low expression of CD146. These results suggest that CD146 is useful in early diagnosis and associated with poor prognosis of malignant pleural mesothelioma.
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Report
(4 results)
Research Products
(11 results)
