Induction of transplantable myogenic cells from pluripotent stem cells
| Project/Area Number |
24590497
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
SUZUKI Yuko 独立行政法人国立精神・神経医療研究センター, 神経研究所・遺伝子疾患治療研究部, 室長 (00342931)
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| Co-Investigator(Kenkyū-buntansha) |
TAKEDA Shin'ichi 国立精神・神経医療研究センター, 神経研究所・遺伝子疾患治療研究部, 部長 (90171644)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 幹細胞 / 再生医療 / iPS細胞 / ジストロフィン / 筋ジストロフィー / 骨格筋 / 移植 / 人工多能性幹細胞 / 再生医学 |
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| Outline of Final Research Achievements |
Induced pluripotent stem cells are a promising tool for regenerative medicine of muscular dystrophies. Here, we compared the cell surface antigens on human myoblasts and human fibroblasts, and found that CD56 and CD271 specifically recognize human myoblasts. Next, we tested whether EZ-sphere method is effective to induce transplantable muscle stem/progenitor cells by transplantation into immunodeficient mdx mice (DMD model mice) and found that iPS-derived muscle stem/progenitor cells participate in muscle regeneration.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Doublecortin marks a new population of transiently amplifying muscle progenitor cells and is required for myofiber maturation during skeletal muscle regeneration.2015
Author(s)
Ogawa R, Ma Y, Yamaguchi M, Ito T, Watanabe Y, Ohtani T, Murakami S, Uchida S, De Gaspari P, Uezumi A, Nakamura M, Miyagoe-Suzuki Y, Tsujikawa K, Hashimoto N, Braun T, Tanaka T, Takeda S, Yamamoto H, Fukada S
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Journal Title
Development.
Volume: 142
Pages: 51-61
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] G-CSF supports long-term muscle regeneration in mouse models of muscular dystrophy.2015
Author(s)
Hayashiji N, Yuasa S, Miyagoe-Suzuki Y, Hara M, Ito N, Hashimoto H, Kusumoto D, Seki T, Tohyama S, Kodaira M, Kunitomi A, Kashimura S, Takei M, Saito Y, Okata S, Egashira T, Endo J, Sasaoka T, Takeda S, Fukuda K
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Journal Title
Nat Commun.
Volume: 6
Pages: 6745-6745
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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