Immunosuppressions by extracellular vesicles secreted from Schistosoma japonicum
| Project/Area Number |
24590503
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
KUMAGAI Takashi 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (40369054)
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| Co-Investigator(Renkei-kenkyūsha) |
OHTA Nobuo 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (10143611)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 細胞外小胞 / 住血吸虫 / miRNA / 赤血球 / エクソソーム / マイクロベシクル / 免疫抑制 / 性成熟 / 分泌型小胞 / スフィンゴミエリナーゼ / GW4869 / BAPTA-AM / エキソソーム / IFN-g / IL-4 / IL-10 |
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| Outline of Final Research Achievements |
Schistosoma japonicum, which is endemic in Asia, parasitizes in the blood vesicles of mammalian hosts. They takes erythrocytes for their reproductive activities. In present study, we focused the extracellular vesicles, which is widely observed in the organisms as vital mobile particles. As the results, the extra cellular vesicles secrete from adult worms, after male and female worms became to be paired, and after they took in the erythrocytes. Furthermore, we found abundant miRNAs, which regulate the targeting genes at the mRNA levels, in their vesicles. This means that the extracellular vesicles have roles on the male-female communications using gene-regulations by miRNAs. Finally, this vesicles also have roles on the suppression to Th1 cytokine productions. Taken together with our results, the extracellular vesicles secreted from S. japonicum, may be required in reproductive activities and immune evasions.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Immunogenicity and anti-fecundity effect of nanoparticle coated glutathione S-transferase (SjGST) DNA vaccine against murine Schistosoma japonicum infection.2015
Author(s)
Mbanefo EC, Kumagai T, Kodama Y, Kurosaki T, Furushima-Shimogawara R, Cherif MS, Mizukami S, Kikuchi M, Huy NT, Ohta N, Sasaki H, Hirayama K.
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Journal Title
Parasitol Int.
Volume: 64
Issue: 4
Pages: 24-31
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A new surveillance and response tool: risk map of infected Oncomelania hupensis detected by Loop-mediated isothermal amplification (LAMP) from pooled samples.2015
Author(s)
Tong QB, Chen R, Zhang Y, Yang GJ, Kumagai T, Furushima-Shimogawara R, Lou D, Yang K, Wen LY, Lu SH, Ohta N, Zhou XN.
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Journal Title
Acta Trop.
Volume: 141
Pages: 170-177
DOI
Related Report
Peer Reviewed
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[Journal Article] Molecular genotyping of anisakis larvae in Middle Eastern Japan and endoscopic evidence for preferential penetration of normal over atrophic mucosa.2014
Author(s)
Arai T, Akao N, Seki T, Kumagai T, Ishikawa H, Ohta N, Hirata N, Nakaji S, Yamauchi K, Hirai M, Shiratori T, Kobayashi M, Fujii H, Ishii E, Naito M, Saitoh S, Yamaguchi T, Shibata N, Shimo M, Tokiwa T.
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Journal Title
PLoS One.
Volume: 9(2)
Issue: 2
Pages: e89188-e89188
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Basophil depletion downregulates Schistosoma mansoni egg-induced granuloma formation2013
Author(s)
Anyan, W.K., Seki, T., Kumagai, T., Obata-Ninomiya, K., Furushima-Shimogawara, R., Kwansa-Bentum, B., Akao, N., Bosompem, K.M., Boakye, D.A., Wilson, M.D., Karasuyama, H., and Ohta, N.
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Journal Title
Parasitol. Int.
Volume: 62
Issue: 6
Pages: 508-513
DOI
Related Report
Peer Reviewed
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