Analysis of the networks of the two-component sensor proteins in Streptococcus pyogenes
Project/Area Number |
24590531
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Bacteriology (including Mycology)
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Research Institution | Nagoya City University |
Principal Investigator |
HASEGAWA Tadao 名古屋市立大学, 医学(系)研究科(研究院), 教授 (10314014)
|
Co-Investigator(Kenkyū-buntansha) |
TATSUNO Ichiro 名古屋市立大学, 大学院医学研究科, 講師 (50311642)
ISAKA Masanori 名古屋市立大学, 大学院医学研究科, 助教 (40336673)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | A群レンサ球菌 / 二成分制御系因子 / 環境ストレス / 病原性 / 遺伝子制御 / 遺伝子発現 |
Outline of Final Research Achievements |
We analyzed the two-component regulatory systems that function by forming networks to sense the environmental stresses in Streptococcus pyogenes. Our analyses suggested that several sensor proteins are involved in sensing acid and also in oxidative stress and biofilm formation. We have found novel isolates that are considered to gain more virulence-associated factors by the analysis of one sensor protein. In addition we confirmed that CovS sensor protein plays important roles that S. pyogenes invades to aseptic tissues from septic tissues by the analysis of the several isolates from a single streptococcal-toxic-shock-syndrome patient.
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Report
(4 results)
Research Products
(12 results)