Elucidation of serum-induced sterol uptake in Pathogenic fungi
| Project/Area Number |
24590540
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Suzuka University of Medical Science |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
CHIBANA Hiroji 千葉大学, 真菌医学研究センター, 准教授 (30333488)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 微生物 / 感染症 / 発現制御 / 脂質 / シグナル伝達 |
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| Outline of Final Research Achievements |
Limited uses of antifungals due to narrow spectrum and severe side effects motivate the development of novel antifungals and therapy. Elucidation of stress response mechanisms and/or isolation of virulence factors is necessary steps to address this.
Sterol uptake would participate in infection process in a pathogenic fungus, Candida glabrata, since this sterol uptake is induced by adding serum. As the first step to understand mechanism of serum-induced sterol uptake, we revealed the four things describing as follows: 1) iron depletion by host factor such as transferrin induces sterol uptake, 2) a mouse infection model demonstrated that a sterol transporter CgAUS1 contribute to infection process, 3) a monnoprotein CgTIR3 participates in sterol uptake and its expression is controlled by UPC2A and UPC2B as well as the CgAUS1 gene, 4) the factor(s) other than CgAUS1 and CgTIR3 would be required for sterol uptake.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] The Candida glabrata sterol scavenging mechanism, mediated by the ATP-binding cassette transporter Aus1p, is regulated by iron limitation.2013
Author(s)
Nagi M, Tanabe K, Ueno K, Nakayama H, Aoyama T, Chibana H, Yamagoe S, Umeyama T, Oura T, Ohno H, Kajiwara S, Miyazaki Y.
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Journal Title
Mol Microbiol.
Volume: 88
Issue: 2
Pages: 371-81
DOI
Related Report
Peer Reviewed
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