Mechanism of anti-pruritic action of histamine H4 receptor antagonist and its usefulness in the treatment of itching dermatitis.
| Project/Area Number |
24590723
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pain science
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| Research Institution | Chiba University |
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Principal Investigator |
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| Research Collaborator |
SUWA Eriko
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | H4受容体拮抗薬 / ステロイド長期塗布誘発掻痒 / プロスタグランジンD2 (PGD2) / ケラチノサイト / サブスタンスP (SP) / ヒスタミン / マウス / 正常ヒト角化細胞 (NHEK) / 掻痒 / デキサメタゾン (DEX) / H4受容体アンタゴニスト (H4RA) / 一酸化窒素 (NO) / dexamethasone / H4受容体アンタゴニスト / ロイコトリエンB4 (LTB4) / LTA4 hydrolase inhibitor / サブスタンスP急性掻痒 / 痒み |
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| Outline of Final Research Achievements |
Topical glucocorticoids are the first-line therapy for chronic dermatitis. We previously reported that long-term topical glucocorticoids exacerbated pruritus in chronic dermatitis model mice. In this study, we clarified that oral dose of histamine H4 receptor antagonist prevented the worsening of pruritus, and additionally suppressed the inflammation. These results indicated that H4 receptor antagonist would be useful for prevention of the exacerbation of pruritus induced by topical glucocorticoids in patients with chronic dermatitis.
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Report
(4 results)
Research Products
(38 results)
