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Clarification of sick building syndrome of a nose by indoor air polutant 2-ethyl-1-hexanol

Research Project

Project/Area Number 24590752
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Hygiene
Research InstitutionNagoya City University

Principal Investigator

MIYAKE Mio  名古屋市立大学, 医学(系)研究科(研究院), 研究員 (80128610)

Co-Investigator(Kenkyū-buntansha) SAKAMOTO Tatsuo  中京大学, スポーツ科学部, 教授 (60262896)
Co-Investigator(Renkei-kenkyūsha) KAMIJIMA Michihiro  名古屋市立大学, 大学院医学研究科, 教授 (80281070)
ITO Yuki  名古屋市立大学, 大学院医学研究科, 講師 (80452192)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords2-エチル-1-ヘキサノール / olfactory marker protein
Outline of Final Research Achievements

2-ethyl-1-hexanol (2E1H) is reported to be one of the causative VOCs of sick building syndrome(SBS) and be associated with increased sense of smell. The goal of this investigation is to clarify histopathological changes due to subchronic inhalation exposure to 2E1H on the olfactory system, especially olfactory epithelium (OE) of the nasal cavity and the olfactory bulb (OB).Male ICR mice were exposed to 0, 20, 60, or 150 ppm of 2E1H, 8 hours per day, for continuous 1 week, 1 month, or 3 months and sacrificed for histopathological evaluation of OE and OB.
2E1H inhalation induced inflammation, degeneration, necrosis, desquamation or disarranged alteration in OE after exposure for 1 week and 3 months, and 3-month exposure resulted in the subsequent alteration in the number of functional cell components in OB which olfactory nerves innervate. Thus it might be suggested that the findings were associated with 2E1H-induced SBS.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (5 results)

All 2014 2013 2012

All Presentation (5 results)

  • [Presentation] 2-エチル-1-ヘキサノール吸入曝露によるマウス嗅覚きへの影響2014

    • Author(s)
      三宅美緒
    • Organizer
      第42回産衛中毒・生物学的モニタリング研究会
    • Place of Presentation
      松本市中央公民館(長野県)
    • Year and Date
      2014-10-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] マウスにおける2-エチルー1-ヘキサノール吸入曝露後の嗅球への影響2014

    • Author(s)
      三宅美緒
    • Organizer
      第87回日本産業衛生学会
    • Place of Presentation
      岡山コンベンションセンター(岡山県)
    • Year and Date
      2014-05-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] 2-エチル-1-ヘキサノール曝露によるマウス鼻粘膜の構造変化と炎症細胞浸潤2013

    • Author(s)
      三宅美緒
    • Organizer
      第86回日本産業衛生学会
    • Place of Presentation
      ひめぎんホール1階(愛媛県)
    • Related Report
      2013 Research-status Report
  • [Presentation] 2-エチル-1-ヘキサノール曝露によるマウス鼻粘膜の構造変化と炎症細胞浸潤2013

    • Author(s)
      三宅美緒
    • Organizer
      第86回日本産業衛生学会
    • Place of Presentation
      ひめぎんホール(愛媛県)
    • Related Report
      2012 Research-status Report
  • [Presentation] 2-エチル-1-ヘキサノールによるマウス気道への影響2012

    • Author(s)
      三宅美緒
    • Organizer
      第85回日本産業衛生学会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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