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Epigenetic analysis of the dementia progression in the sleep disordered breathing patients

Research Project

Project/Area Number 24590882
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General internal medicine (including Psychosomatic medicine)
Research InstitutionOsaka University

Principal Investigator

ITO Norihisa  大阪大学, 医学(系)研究科(研究院), 助教 (00621757)

Co-Investigator(Kenkyū-buntansha) RAKUGI Hiromi  大阪大学大学院医学系研究科, 老年・腎臓内科学, 教授 (20252679)
OHISHI Mitsuru  鹿児島大学大学院医歯学総合研究科, 心臓血管・高血圧内科学, 教授 (50335345)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords閉塞性睡眠時無呼吸 / 筋力 / 身体能力 / 認知機能 / 睡眠呼吸障害
Outline of Final Research Achievements

In this study, we designed a clinical investigation to clarify the association between the severity of obstructive sleep apnea (OSA) and cognitive function, depression, activities of daily life, muscle strength, physical performance, and cardiovascular event. We found that the muscle strength and physical performance in severe OSA group were significantly lower than mild-moderate OSA group in elderly. And we found that the left ventricular diastolic function in severe OSA group was significantly lower than mild-moderate OSA group in hypertensive patients. And we are monitoring the effect of continuous positive airway pressure and performing the epigenetic sequencing.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (6 results)

All 2014 Other

All Presentation (6 results)

  • [Presentation] 閉塞性睡眠時無呼吸を有する高血圧患者の心機能についての検討2014

    • Author(s)
      伊東範尚
    • Organizer
      第37回日本高血圧学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-10-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] The association between obstructive sleep apnea severity and sarcopenia in the elderly2014

    • Author(s)
      伊東範尚
    • Organizer
      10th International Congress of the European Union Geriatric Medicine Society
    • Place of Presentation
      ロッテルダム(オランダ)
    • Year and Date
      2014-09-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] 閉塞性睡眠時無呼吸を有する高齢者における筋力・身体能力と閉塞性睡眠時無呼吸の重症度の関連性についての検討2014

    • Author(s)
      伊東範尚
    • Organizer
      第56回日本老年医学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2014-06-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] 閉塞性睡眠時無呼吸患者の無呼吸低呼吸評価法とbaPWVの関係2014

    • Author(s)
      伊東範尚
    • Organizer
      第14回臨床血圧脈波研究会
    • Place of Presentation
      東京
    • Year and Date
      2014-06-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] 閉塞性睡眠時無呼吸患者の無呼吸低呼吸評価法とbaPWVの関係

    • Author(s)
      (a)伊東範尚(b)武田昌生、小黒亮輔、前川佳敬、鷹見洋一、竹屋泰、山本浩一、杉本研、樂木宏実
    • Organizer
      第14回臨床血圧脈波研究会
    • Place of Presentation
      品川インターシティホール(東京都)
    • Related Report
      2013 Research-status Report
  • [Presentation] 閉塞性睡眠時無呼吸を有する高齢者における筋力・身体能力と閉塞性睡眠時無呼吸の重症度の関連性についての検討

    • Author(s)
      (a)伊東範尚(b)安延由紀子、武田昌生、小黒亮輔、前川佳敬、鷹見洋一、竹屋泰、山本浩一、杉本研、樂木宏実
    • Organizer
      第56回日本老年医学会学術集会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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