Study on clinical isolation and identification of elderly tauopathies in elderly dementia patients

• Project/Area Number: 24590894
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: Osaka City University
• Principal Investigator: SHIMADA Hiroyuki 大阪市立大学, 大学院医学研究科, 特任教授 (90254391)
• Co-Investigator(Kenkyū-buntansha): 安宅 鈴香 大阪市立大学, 大学院医学研究科, 医員 (40549755) ; 渡辺 恭良 (渡邊 恭良) 大阪市立大学, 大学院医学研究科, 特任教授 (40144399) ; 三木 隆己 大阪市立大学, 大学院医学研究科, 教授 (90174002)
• Project Period (FY): 2012-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: アミロイドPET / アルツハイマー病 / 高齢者タウオパチー / アミロイド陰性認知症 / MRI / 老年期認知症 / アルツハイマー型認知症 / 嗜銀顆粒性認知症 / 神経原線維変化型認知症 / PiB陰性認知症 / PIB陰性認知症

Outline of Final Research Achievements

Amyloid imaging was developed as a method to visualize senile plaques in the brain, but we found that among patients diagnosed as clinically Alzheimer's disease, patients with negative PIB-PET and no evidence of accumulation of amyloid in the brain Was found to exist. We named these patient groups as PIB-negative dementia (PND), and its background pathology includes elderly tauopathies (argyrophilic grain dementia and neurofibrillary dementia) and frontotemporal dementia. In this study, PND patients who were clinically diagnosed with Alzheimer type dementia and elderly people over 80 years old who had negative amyloid imaging were extracted as subjects, and their clinical images were compared with patients with Alzheimer's disease dementia of 80 years or older (AD). As a result, neuropsychological examination showed a low value in the AD group, but no significant difference was observed in MRI and FDG-PET.There is significant differences in the CSF biomarker.

Research Products

• [Journal Article] Brain uptake and safety of Flutemetamol F 18 injection in Japanese subjects withprobable Alzheimer’s disease, subjects withamnestic mild cognitive impairment andhealthy volunteers (2017)
  • Author(s): Takami Miki,Hiroyuki Shimada, Jae;Seung Kim, Yasuji Yamamoto, Masakazu Sugino, Hisatomo Kowa, Kerstin Heurling, Michelle Zanette, Paul F. Sherwin, Michio Senda
  • Journal Title: Annals of Nuclear Medicine Volume: 50 Issue: 3 Pages: 117-125
  • DOI: 10.1007/s12149-017-1154-7
  • Peer Reviewed
• [Journal Article] Serum Levels of Albumin-B-Amyloid Complex in Patients with Depression. (2016)
  • Author(s): Inoue M, Baba H, Yamamoto K, Shimada H, Yamakawa Y, Suzuki T, Miki T, Arai H,
  • Journal Title: Am J Geriatr Psychiatry Volume: 24 Issue: 9 Pages: 764-772
  • DOI: 10.1016/j.jagp.2016.05.005
  • Peer Reviewed
• [Journal Article] PARK 16 polymorphism, interaction with smoking, and sporadic Parkinson’s disease in Japan (2016)
  • Author(s): Y. Miyake, K. Tanaka, W. Fukushima, C.Kiyohara, S. Sasaki, Y.Tsuboi, T.Oeda,H.Shimada,
  • Journal Title: Journal of the Neurological Science Volume: 362 Pages: 47-52
  • DOI: 10.1016/j.jns.2016.01.021
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Randomized double-blind placebo-controlled multicenter trial of Yokukansan for neuropsychiatric symptoms in Alzheimer's disease. (2016)
  • Author(s): K.Furukawa,N.Tomita,D.Uematsu, K. Okahara, H.Shimada,
  • Journal Title: Geriatr Gerontol Int. Volume: 印刷中 Issue: 2 Pages: 1-8
  • DOI: 10.1111/ggi.12696
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Cerebral infarction in the left hemisphere compared with the right hemisphere increases the risk of aspiration pneumonia. (2014)
  • Author(s): Yamamoto K., Koh H., Shimada H.,Takeuchi J., Yamakawa Y., Kawamura M., Miki T.
  • Journal Title: Osaka City Med J Volume: 60 Pages: 81-86
  • NAID: 120006493296
  • Peer Reviewed
• [Journal Article] Serum levels of albumin-amyloid beta complexes are decreased in Alzheimer's disease. (2014)
  • Author(s): Yamamoto K., Shimada H., Koh H., Ataka S., Miki T.
  • Journal Title: Geriatr Gerontol Int Volume: 14 Pages: 716-723
  • Peer Reviewed
• [Journal Article] Diffusion-Weighted Imaging Thermometry in Multiple Sclerosis. (2014)
  • Author(s): Asari Sai, Taro Shimono, Koji Sakai, Akitoshi Takeda, Hiroyuki Shimada, Taro Tsukamoto, Hiroko Maeda, Shinichi Sakamoto,Yukio Miki
  • Journal Title: Journal of Magnetic Resonance Imaging. Volume: 40 Pages: 649-654
  • Peer Reviewed
• [Journal Article] Serum levels of albumin-amyloid beta complexes are decreased in Alzheimer's disease. (2013)
  • Author(s): Yamamoto K, Shimada H, Koh H, Ataka S, Miki T.
  • Journal Title: Geriatr Gerontol Int. Volume: 13 Issue: 3 Pages: 241-246
  • DOI: 10.1111/ggi.12147
  • Peer Reviewed
• [Journal Article] A case of anti-N-metyl-D- aspartate receptor encephalitis with Multiple Sclerosis-like demyelinated lesions (2013)
  • Author(s): A.Takeda1, H.Shimada, A.Tamura, M. Yasui, K.Yamamoto, K.Itoh, S.Ataka, S. Tanaka, M.Ohsawa, H.Hatsuta, H.Sakamoto, M.Hirano, S.Ueno, Y.Nakamura, T.Tsutada, T.Miki
  • Journal Title: Multiple Sclerosis and Related disorders Volume: ６ Pages: 391-397
  • Peer Reviewed
• [Journal Article] Clinical features of Pittsburgh compound-B-negative dementia (2012)
  • Author(s): Takeuchi Jun
  • Journal Title: Dementia and Geriatric Cognitive Disorders Volume: 34 Issue: 2 Pages: 112-120
  • DOI: 10.1159/000341577
  • Peer Reviewed
• [Journal Article] Derlin-1-immunopositive inclusions in patients with Alzheimer's disease. (2012)
  • Author(s): Honjo Y, Ito H, Horibe T, Shimada H, Nakanishi A, Mori H, Takahashi R, Kawakami K.
  • Journal Title: Neuroreport Volume: 11 Issue: 10 Pages: 611-615
  • DOI: 10.1097/wnr.0b013e3283552a75
  • Peer Reviewed
• [Journal Article] SNCA polymorphisms, smoking, and sporadic Parkinson's disease in Japanese. (2012)
  • Author(s): Miyake Y, Tanaka K, Fukushima W, Kiyohara C, Sasaki S, Tsuboi Y, Yamada T, Oeda T, Shimada H, Kawamura N, Sakae N, Fukuyama H, Hirota Y, Nagai M, Group FKPsDS
  • Journal Title: Parkinsonism and Related Disorders Volume: 18 Issue: 5 Pages: 557-561
  • DOI: 10.1016/j.parkreldis.2012.02.016
  • Peer Reviewed
• [Journal Article] Reduced interhemispheric inhibition in mild cognitive impairment. (2012)
  • Author(s): Tsutsumi R, Hanajima R et al.
  • Journal Title: Exp Brain Res Volume: 218 Issue: 1 Pages: 21-26
  • DOI: 10.1007/s00221-011-2997-0
  • Peer Reviewed
• [Journal Article] Dietary patterns and risk of Parkinson's disease : a case-control study in Japan (2012)
  • Author(s): Okubo H, et al
  • Journal Title: Eur J Neurol Volume: (掲載確定)(印刷中)(in press) Issue: 5 Pages: 681-688
  • DOI: 10.1111/j.1468-1331.2011.03600.x
  • Peer Reviewed
• [Presentation] .高齢者タウオパチーにおけるタウイメージング (2015)
  • Author(s): 嶋田裕之
  • Organizer: 第56回日本神経学会
  • Place of Presentation: 新潟、朱鷺メッセ
  • Year and Date: 2015-05-20
• [Presentation] Decreased Serum Levels of Albumin-Tau Complexes are valuable biomarker for distinguishing behavioral variant Frontotemporal Dementia from Alzheimer's Disease with Pittsburgh compound B-positron emission tomography confirmation. (2014)
  • Author(s): K. Yamamoto, H. Shimada, S. Ataka, Y. Yamakawa, T.Miki.
  • Organizer: Alzheimer's Association International Conference
  • Place of Presentation: Copenhagen, Denmark
  • Year and Date: 2014-07-16
• [Presentation] Blinded visual evaluation and quantitative SUVR threshold classification of 18F Flutemetamol PET. (2014)
  • Author(s): Kerstin Heruling, Takami Miki, Hiroyuki Shimada
  • Organizer: Alzheimer's Association International Conference
  • Place of Presentation: Copenhagen, Denmark
  • Year and Date: 2014-07-12
• [Presentation] 多発性硬化症患者における疲労とうつ－認知機能障害との関連－ (2014)
  • Author(s): 武田景敏, 田中雅彰， 石井聡， 小山慎一， 中富康仁， 安宅鈴香
  • Organizer: 第55回 日本神経学会学術大会
  • Place of Presentation: 福岡国際会議場（福岡県、福岡市）
  • Year and Date: 2014-05-23
• [Presentation] Serum Levels of Albumin-Amyloid Beta Complexes are Decreased in Alzheimer’s Disease (2013)
  • Author(s): Keiichi Yamamoto1,Hiroyuki Shimada, Hideo Koh, Suzuka Ataka,Takami Miki
  • Organizer: Alzheimer's Association International Conference
  • Place of Presentation: アメリカ、ボストン、ボストンコンベンションセンター
• [Presentation] Serum levels of albumin-amyloid beta complexes are useful for monitoring of progression of Alzheimer’s disease (2013)
  • Author(s): K.Yamamoto, H.Shimada, S.Ataka, T,Miki.
  • Organizer: World Congress of Neurology
  • Place of Presentation: オーストリア ウィーン、ウィーンエキシビション、コングレスセンター
• [Presentation] Clinical features of Pittsburgh Compound-B-negative dementia (2012)
  • Author(s): J Takeuchi H Shimada S Ataka J Kawabe H Mori K Mizuno Y Wada S Shiomi Y Watanabe, T Miki
  • Organizer: Alzheimer's Association International Conference
  • Place of Presentation: Vancouber、バンクーバーコンベンションセンター
• [Presentation] 臨床的にADと診断されPiB-PETが陰性でFTLDが疑われた６症例の検討 (2012)
  • Author(s): 安宅鈴香、嶋田裕之、竹内潤、高橋和弘、和田康弘、武田景敏、山川義宏、田村暁子、山本圭一、伊藤和博、蔦田強司、塩見 進、渡邊恭良、三木隆己
  • Organizer: 第53回 日本神経学会総会
  • Place of Presentation: 東京、東京フォーラム
• [Presentation] アルツハイマー病の早期診断・治療のためのガイドラインに向けて：prodromal AD、Pre-MCI (2012)
  • Author(s): 嶋田 裕之
  • Organizer: 第31回日本認知症学会学術集会 シンポジウム２
  • Place of Presentation: つくば、つくば国際会議場
• [Remarks] 大阪市立大学医学部老年科・神経内科 業績
  • URL: http://www.med.osaka-cu.ac.jp/GeriatNeuro/achievements.html