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情動的ストレスによる心血管系の応答に対する圧受容体機能の役割

Research Project

Project/Area Number 24590895
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General internal medicine (including Psychosomatic medicine)
Research InstitutionWakayama Medical University

Principal Investigator

上山 敬司  和歌山県立医科大学, 医学部, 教授 (50264875)

Co-Investigator(Kenkyū-buntansha) 羽野 卓三  和歌山県立医科大学, 医学部, 教授 (90156381)
鶴尾 吉宏  徳島大学, 大学院医歯薬研究部, 教授 (90207449)
Project Period (FY) 2012 – 2016
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords圧受容体反射 / 情動性ストレス / 情動的ストレス / 神経解剖学 / 逆行性トレーサー / c-Fos / ストレス / Stress
Outline of Annual Research Achievements

圧受容体反射経路と情動的ストレスの回路で、共通する箇所を神経解剖学的手法で探索することを探索することを目標とした。圧受容体反射弓除神経群とSham群で、不動化(情動的)ストレスで変化する領域として不確体や淡蒼球縫線核が抽出された。そこでより上位の自律神経から影響され、また圧受容体反射経路からは上位にあたると考えられる分界条床核(BST)に注目し、その求心路を逆行性トレーサーChlera toxin b subunit(CTb)をBSTに注入し、ストレス負荷を加え、CTbと神経興奮マーカーであるc-Fosとの二重染色を行い、mappingを行った。CTbをLSDの一部と中隔海馬采や三角中隔核に注入し、側脳室に漏れた。CTb陽性細胞としては、辺縁系として知られるD1・島皮質(GI)、帯状回(Cg)、下辺縁皮質(IL)、前辺縁皮質(PrL)、背側脚皮質(DP)やそれ以外の大脳皮質としも運動野(M1、M2)、感覚野(S1, S2)の場所に見られた。また、視床下部として腹側内側核(VMH)、視索前野(LPO, MPA)、ブローカの体格帯(HDB, VDB)が見られ、小脳皮質巣小葉(Sim)、中脳の淡蒼縫線核(RPa)の場所でも観察することができた。次にCTbとcFos二重陽性は中脳の青斑核(LC)、延髄の尾側オリーブ周囲核(CPO)、視床下部室傍核(PaLM)、視床下部外側核(LH)の場所で見られた。

Report

(5 results)
  • 2016 Annual Research Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (36 results)

All 2017 2016 2015 2014 2013 2012 Other

All Journal Article (18 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 14 results,  Open Access: 9 results,  Acknowledgement Compliant: 6 results) Presentation (17 results) (of which Invited: 5 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] 【たこつぼ症候群】分子メカニズム2016

    • Author(s)
      上山敬司
    • Journal Title

      心臓

      Volume: 48 Pages: 1138-1141

    • Related Report
      2016 Annual Research Report
  • [Journal Article] ストレス応答の形態学的理解(総説)2016

    • Author(s)
      上山敬司
    • Journal Title

      和歌山医学

      Volume: 67 Pages: 46-49

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Gene expression profiling in rats with depressive-like behavior2015

    • Author(s)
      Yamamoto Y, Ueyama T, Ito T, Tsuruo Y
    • Journal Title

      Genom Data

      Volume: 11 Issue: 5 Pages: 279-280

    • DOI

      10.1016/j.gdata.2015.04.030

    • NAID

      120006650108

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Down-regulation of growth hormone 1 gene in the cerebellum and prefrontal cortex of rats with depressive-like behavior.2015

    • Author(s)
      Yamamoto Y, Ueyama T, Ito T, Tsuruo Y.
    • Journal Title

      Physiological Genomics

      Volume: 0 Issue: 5 Pages: 0-0

    • DOI

      10.1152/physiolgenomics.00119.2014

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Alterations of regional cerebral blood flow in tinnitus patients as assessed using single-photon emission computed tomography2015

    • Author(s)
      Ueyama T, Donishi T, Ukai S, Yamamoto Y, Ishida T, Tamagawa S, Hotomi M, Shinosaki K, Yamanaka N, Kaneoke Y
    • Journal Title

      PLoS One

      Volume: 10 Issue: 9 Pages: e0137291-e0137291

    • DOI

      10.1371/journal.pone.0137291

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cardiovascular responses to microinjections of endomorphin-2 into the nucleus of the solitary tract are attenuated in the spontaneously hypertensive rat2015

    • Author(s)
      Kawabe T, Ueyama T, Hano T, Sapru HN
    • Journal Title

      Clin Exp Hypertens

      Volume: 37 Issue: 3 Pages: 197-205

    • DOI

      10.3109/10641963.2014.933969

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Semaphorin 4D induces vaginal epithelial cell apoptosis to control mouse postnatal vaginal tissue remodeling.2015

    • Author(s)
      Ito T, Bai T, Tanaka T; Yoshida K, Ueyama T, Miyajima M, Negishi T, Kawasaki T, Takamatsu H, Kikutani H, Atsushi Kumanogoh A, Yukawa K
    • Journal Title

      Mol Med Rep

      Volume: 11 Issue: 2 Pages: 829-836

    • DOI

      10.3892/mmr.2014.2773

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 扁桃体と中枢自律神経系2014

    • Author(s)
      上山敬司、田根志帆、水本 結
    • Journal Title

      Clinical Neuroscience

      Volume: 32 Pages: 648-651

    • Related Report
      2014 Research-status Report
  • [Journal Article] Nrf2-induceding anti-oxidation stress response in the liver - New beneficial effect of Lansoprazole2014

    • Author(s)
      Yamashita Y, Ueyama T, Nishi T, Yamamoto Y, Kawakoshi A, Sunami S, Iguchi M, Tamai H, Ueda K, Ito T, Tsuruo Y, Ichinose M
    • Journal Title

      PLoS ONE

      Volume: 9(5) Issue: 5 Pages: e97419-e97419

    • DOI

      10.1371/journal.pone.0097419

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reduction of cortical excitability and increase of thalamic activity in a low-frequency rTMS treatment for chronic tinnitus.2014

    • Author(s)
      Takahashi S, Ukai S, Tsuji T, Ueyama T, Kono M, Yamanaka N, Shinosaki K
    • Journal Title

      Neurocase

      Volume: 10 Pages: 1-6

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Estrogen-dependent proteolytic cleavage of Semaphorin 4D and Plexin-B1 enhances Semaphorin 4D-induced apoptosis during postnatal vaginal remodeling in pubescent mice.2014

    • Author(s)
      Ito T, Bai T, Tanaka T; Yoshida K, Ueyama T, Miyajima M, Negishi T, Kawasaki T, Takamatsu H, Kikutani H, Atsushi Kumanogoh A, Yukawa K
    • Journal Title

      PLoS ONE

      Volume: 9 Issue: 5 Pages: e97909-e97909

    • DOI

      10.1371/journal.pone.0097909

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Cardiovascular responses to microinjections of endomorphin-2 into the nucleus of the solitary tract are attenuated in the spontaneously hypertensive rat.2014

    • Author(s)
      Kawabe T, Ueyama T, Hano T, Sapru
    • Journal Title

      Clin. Exp. Hyper.

      Volume: 22 Pages: 1-10

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Neuroanatomy of Stress Responses2013

    • Author(s)
      Ueyama T
    • Journal Title

      Advances in Neuroimmune Biology

      Volume: 4 Pages: 13-33

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Is gastrectomy-induced high turnover of bone with hyperosteoidosis and increase of mineralization a typical osteomalacia?2013

    • Author(s)
      Ueyama T, Yamamoto Y, Ueda K, Yajima A, Maeda Y, Yamashita Y, Ito T, Tsuruo Y, Ichinose M
    • Journal Title

      PLoS ONE

      Volume: 8(6) Issue: 6 Pages: e65685-e65685

    • DOI

      10.1371/journal.pone.0065685

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Brain regions responsible for tinnitus distress and loudness: a resting-state fMRI study.2013

    • Author(s)
      Ueyama T, Donishi T, Ukai S, Ikeda Y, Hotomi M, Yamanaka N, Shinosaki K, Terada M, Kaneoke Y.
    • Journal Title

      PLoS ONE

      Volume: 8 (6) Issue: 6 Pages: 1-12

    • DOI

      10.1371/journal.pone.0067778

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Azelnidipine, unique calcium channel blocker could prevent stress-induced cardiac dysfunction like ab blocker2012

    • Author(s)
      Takano Y, Ueyama T, Ishikura F
    • Journal Title

      J Cardiol

      Volume: 60 Issue: 1 Pages: 18-22

    • DOI

      10.1016/j.jjcc.2012.01.017

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Acute effects of beta-blocker with intrinsic sympathomimetic activity on stress-induced cardiac dysfunction in rats.2012

    • Author(s)
      Ishikura F, Takano Y, Ueyama T
    • Journal Title

      J Cardiol

      Volume: 60 Issue: 6 Pages: 470-474

    • DOI

      10.1016/j.jjcc.2012.07.004

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 情動、扁桃体と自律神経系2012

    • Author(s)
      上山敬司
    • Journal Title

      Brain and Nerve

      Volume: 64 Pages: 1113-1119

    • Related Report
      2012 Research-status Report
  • [Presentation] 有酸素運動によるうつ様行動軽減効果についての解析2017

    • Author(s)
      山本悠太、山岸直子、伊藤隆雄、上山敬司
    • Organizer
      第122回 日本解剖学会総会
    • Place of Presentation
      長崎県長崎市
    • Year and Date
      2017-03-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] ランソプラゾールはNrf2/Ho1経路を活性化することによって肝細胞障害を抑制する2017

    • Author(s)
      山岸直子、山本悠太、西利男、伊藤隆雄、上山敬司
    • Organizer
      第122回 日本解剖学会総会
    • Place of Presentation
      長崎県長崎市
    • Year and Date
      2017-03-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] 胃切除によるラット肝臓への影響について2017

    • Author(s)
      伊藤隆雄、山本悠太、山岸直子、上山敬司
    • Organizer
      第122回 日本解剖学会総会
    • Place of Presentation
      長崎県長崎市
    • Year and Date
      2017-03-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] 非アルコール性肝炎(NASH)モデルにおいてランソプラゾールはTGF-β活性を抑制する2016

    • Author(s)
      山本悠太、山岸直子、西利男、上山敬司
    • Organizer
      第11回臨床ストレス応答学会
    • Place of Presentation
      山口県宇部市
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
  • [Presentation] ランソプラゾールはNrf2/HO1経路を活性化することによって肝細胞保護作用を示す2016

    • Author(s)
      山岸直子、山本悠太、西利男、伊藤隆雄、上山敬司
    • Organizer
      第11回臨床ストレス応答学会
    • Place of Presentation
      山口県宇部市
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
  • [Presentation] 耳鳴症患者における相対的脳血流量の相違-SPECTによる解析2015

    • Author(s)
      上山敬司、堂西倫弘、鵜飼 聡、石田卓也、玉川俊次、保富宗城、山中 昇、篠崎和弘、金桶吉起
    • Organizer
      脳機能マッピング学会
    • Place of Presentation
      大阪
    • Year and Date
      2015-07-03
    • Related Report
      2015 Research-status Report
  • [Presentation] . Identification of novel responsible genes for the depressive-like behavior in microarray and pathway analyses.2015

    • Author(s)
      Yamamoto Y, Ueyama T
    • Organizer
      11th Catecholamines and other neurotransmitters in stress
    • Place of Presentation
      Smolenice, Slovakia
    • Year and Date
      2015-06-20
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 耳鳴症の音量と苦痛度に関する脳領域安静時機能的MRIを用いた解析2015

    • Author(s)
      山中 昇、保富宗城、池田頼彦、玉川俊二、金桶吉起、篠崎和弘、上山敬司
    • Organizer
      第116回日本耳鼻咽喉科学会
    • Place of Presentation
      東京
    • Year and Date
      2015-05-20
    • Related Report
      2015 Research-status Report
  • [Presentation] New and multiple aspects of proton pump.2015

    • Author(s)
      上山敬司
    • Organizer
      第120回日本解剖学会総会・全国学術集会第92回日本生理学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21
    • Related Report
      2014 Research-status Report
  • [Presentation] Neuroimagigから見た耳鳴症の解析2015

    • Author(s)
      上山敬司、堂西倫弘、鵜飼聡、池田頼彦、玉川俊二、保富宗城、山中 昇、篠崎和弘、寺田正樹、金桶吉起
    • Organizer
      日本音響学会2015春季大会
    • Place of Presentation
      東京
    • Year and Date
      2015-03-16
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Neuroimaging of brain regions responsible for tinnitus loudness and distress.2014

    • Author(s)
      Ueyama T, Donisho T, Ukai S, Shinosaki K, Hotomi M, Ikeda Y, Tamagawa S, Terada M, Yamanaka N, Kaneoke Y
    • Organizer
      Inner Ear Biology Workshop 2014 in Kyoto.
    • Place of Presentation
      京都
    • Year and Date
      2014-11-03
    • Related Report
      2014 Research-status Report
  • [Presentation] 中枢自律神経系の機能解剖2014

    • Author(s)
      上山敬司
    • Organizer
      第67回日本自律神経学会総会
    • Place of Presentation
      埼玉
    • Year and Date
      2014-10-28
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 耳鳴症の音量と苦痛度に関与する脳領域―安静時機能的MRIを用いた解析2013

    • Author(s)
      上山敬司、堂西倫弘、鵜飼 聡、池田頼彦、保富宗城、山中 昇、篠崎和弘、寺田正樹、金桶吉起
    • Organizer
      第15回日本ヒト脳機能mapping学会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] Afferent projection to amygdaloid subnuclei and intrinsic connection of each subnuclei2012

    • Author(s)
      上山敬司、伊藤隆雄、山本悠太、鶴尾吉宏
    • Organizer
      第 35回日本神経科学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Research-status Report
  • [Presentation] 新時代の解剖学教材の工夫-CTとMRIの画像を用いた3次元人体アトラスの作製の経験

    • Author(s)
      上山敬司
    • Organizer
      第119 回日本解剖学会総会
    • Place of Presentation
      栃木
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 中枢自律神経系への性ホルモンの関与

    • Author(s)
      上山敬司
    • Organizer
      第91回日本生理学会
    • Place of Presentation
      鹿児島
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] ランソプラゾールの新規薬効-肝臓における転写因子Nrf2の誘導と抗酸化ストレス作用

    • Author(s)
      上山敬司、山下泰伸、西 利男、山本悠太、玉井秀樹、伊藤隆雄、鶴尾吉宏、一瀬雅夫
    • Organizer
      第87回日本薬理学会
    • Place of Presentation
      仙台
    • Related Report
      2013 Research-status Report
  • [Patent(Industrial Property Rights)] 「ランソプラゾールの新規医薬用途」2014

    • Inventor(s)
      上山敬司、山本悠太、西 利男、山下泰伸、一瀬雅夫、松尾孝徳
    • Industrial Property Rights Holder
      和歌山県立医科大学武田薬品工業株式会社
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-01-31
    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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