| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Magnetoencephalography (MEG) can detect brain network and synaptic functions very sensitively. The objective of this study, using MEG and amyloid-PET imaging, was to develop functional biomarkers for Alzheimer’s disease (AD) which are useful in the early stages of AD. We found two possible MEG biomarkers as follows: 1) Using somatosensory evoked magnetic field recovery function to paired electric stimuli, the cortical excitability associated with local amyloid deposition can be evaluated. 2) Functional network alterations in asymptomatic elders at risk for AD (amyloid-positive cognitively normal elders) could be detected by assessing functional connectivity of resting-state MEG signals.
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