| Project/Area Number |
24590923
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Gastroenterology
|
|---|
| Research Institution | Nagoya City University |
|---|
Principal Investigator |
Shimura Takaya 名古屋市立大学, 医学(系)研究科(研究院), 講師 (90405192)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
EBI Masahide 愛知医科大学, 医学部, 講師 (40611629)
YOSHIDA Michihiro 名古屋市立大学, 医学研究科, 研究員 (20636328)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
HIGASHIYAMA Shigeki 愛媛大学, 大学院医学系研究科, 教授 (60202272)
|
|---|
| Project Period (FY) |
2012-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | HB-EGF / 胃癌 / 大腸癌 / EGFR / Amphiregulin |
|---|
| Outline of Final Research Achievements |
HB-EGF expression, not intracellular localization of HB-EGF-CTF, in the tumor was one of the predictive factor for anti-EGFR therapy against KRAS wild type metastatic ｃolorectal cancer, as well as other EGFR ligands including amphiregulin, TGF-a, epiregulin (Yoshida M, Shimura T, et al. J Cancer Res Clin Oncol.2013: 367-78).
Urinary level and tumor expression of ADAM12, which regulates HB-EGF-CTF nuclear translocation, is a useful biomarker for early diagnosis of gastric cancer(Yoshida M, Shimura T, et al. J Cancer Res Clin Oncol.2013: 367-78).
|
