| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Outline of Final Research Achievements |
Ischemic limb tissue was highly exposed to oxidative stress and a lot of endothelial progenitor cells injected to the tissue were led to apoptosis before playing the role for augmenting neovascularization in mice. The tissue condition impaired the mitochondria function, the neovascularization-related inflammatory cytokine secretory function, and the glucose transport function of the skeletal muscle cell. A pretreatment with the nebulization of propionate, which is a pharmacologic chemical agent with a potential for curing low oxygen-induced mitochondria dysfunction, for the mouse ischemic limb tissue augmented the recovery of blood flow in the limb that was subsequently injected endothelial progenitor cells. This result might be due to a recovery of the impaired functions of the skeletal muscle cell, suggesting a hint for the development of next-generation therapeutic angiogenesis.
|
