A New Diagnostics Method for Refractory Heart Failure
Project/Area Number |
24591097
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Circulatory organs internal medicine
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Research Institution | Osaka University |
Principal Investigator |
ASANO YOSHIHIRO 大阪大学, 医学(系)研究科(研究院), 助教 (60527670)
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Co-Investigator(Kenkyū-buntansha) |
HIGO Shuichiro 大阪大学, 医学(系)研究科(研究院), 助教 (00604034)
TSUKAMOTO Osamu 大阪大学, 医学(系)研究科(研究院), 助教 (80589151)
MINAMINO Tetsuo 大阪大学, 医学(系)研究科(研究院), 准教授 (30379234)
KATO Hisakazu 大阪大学, 医学(系)研究科(研究院), 特任研究員 (30589312)
OGITA Hisakazu 滋賀医科大学, 医学部, 教授 (50379236)
SANADA Shoji 大阪大学, 医学(系)研究科(研究院), 助教 (70593797)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | エピゲノム / 細胞核クロマチン / 難治性心不全 / 分子循環器病学 / 臨床循環器 |
Outline of Final Research Achievements |
Higher order structures in the cell nucleus have been demonstrated to change during development and differentiation. Such structural remodeling occurred in the cell nucleus can be observed as changes in high electron density areas called chromatin by electron microscopy. Alterations in nuclear chromatin structure have been reported some relation with physiological changes. Based on our experimental findings of chromatin remodeling as an upstream of pathological gene expression in cardiomyocytes, we focused on changes in nuclear chromatin structure of cardiomyocytes in patients with dilated cardiomyopathy (DCM). Using our original quantitation methods to analyze the ultrastructure of chromatin, we conducted a retrospective observational study assessing the ability to identify the DCM patients with severe heart failure at risk for poor outcomes, and to make an accurate and an early determination of the indication for some ventricular assist devices to support the failing heart.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Higd1a is a positive regulator of cytochrome c oxidase.2015
Author(s)
Hayashi T, Asano Y* (corresponding author), Shintani Y, Aoyama H, Kioka H, Tsukamoto O, Hikita M, Shinzawa-Itoh K, Takafuji K, Higo S, Kato H, Yamazaki S, Matsuoka K, Nakano A, Asanuma H, Asakura M, Minamino T, Goto YI, Ogura T, Kitakaze M, Komuro I, Sakata Y, Tsukihara T, Yoshikawa S, Takashima S.
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Journal Title
Proc. Natl. Acad. Sci. USA.
Volume: 112
Pages: 1553-8
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Augmented AMPK activity inhibits cell migration by phosphorylating the novel substrate Pdlim5.2015
Author(s)
Yan Y, Tsukamoto O, Nakano A, Kato H, Kioka H, Ito N, Higo S, Yamazaki S, Shintani Y, Matsuoka K, Liao Y, Asanuma H, Asakura M, Takafuji K, Minamino T, Asano Y, Kitakaze M, Takashima S.
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Journal Title
Nature Communication.
Volume: in press
Pages: in press
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Noninvasive and quantitative live imaging reveals a potential stress-responsive enhancer in the failing heart.2014
Author(s)
Matsuoka K, Asano Y* (corresponding author), Higo S, Tsukamoto O, Yan Y, Yamazaki S, Matsuzaki T, Kioka H, Kato H, Uno Y, Asakura M, Asanuma H, Minamino T, Aburatani H, Kitakaze M, Komuro I, Takashima S.
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Journal Title
FASEB J.
Volume: 28
Pages: 1870-9
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Evaluation of intra-mitochondrial ATP levels identifies G0/G1 switch gene 2 as a positive regulator of oxidative phosphorylation.2014
Author(s)
Kioka A, Kato A, Makoto Fujikawa M, Tsukamoto O, Suzuki T, Imamura H, Nakano A, Higo S, Yamazaki S, Matsuzaki T, Takafuji K, Asanuma H, Asakura M, Minamino T, Shintani Y, Yoshida M, Noji H, Kitakaze M, Komuro I, Asano Y* (corresponding author), Takashima S.
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Journal Title
Proc Natl Acad Sci U S A.
Volume: 111
Pages: 273-8
DOI
Related Report
Peer Reviewed
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[Journal Article] Comprehensive metagenomic approach for detecting causative microorganisms in culture-negative infective endocarditis.2014
Author(s)
Imai A, Gotoh K, Asano Y* (corresponding author), Yamada N, Motooka D, Fukushima M, Kanzaki M, Ohtani T, Sakata Y, Nishi H, Toda K, Sawa Y, Komuro I, Horii T, Iida T, Nakamura S, Takashima S.
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Journal Title
Int J Cardiol.
Volume: 172
Pages: e288-9
DOI
Related Report
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[Journal Article] Usefulness of transient elastography for noninvasive and reliable estimation of right-sided filling pressure in heart failure.2014
Author(s)
Taniguchi T, Sakata Y, Ohtani T, Mizote I, Takeda Y, Asano Y, Masuda M, Minamiguchi H, Kanzaki M, Ichibori Y, Nishi H, Toda K, Sawa Y, Komuro I.
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Journal Title
Am J Cardiol.
Volume: 113
Pages: 552-8
DOI
Related Report
Peer Reviewed
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[Journal Article] Dipeptidyl-Peptidase IV Inhibition Improves Pathophysiology of Heart Failure and Increases Survival Rate in Pressure-Overloaded Mice.2013
Author(s)
Takahashi A, Asakura M, Ito S, Min KD, Shindo K, Yan Y, Liao Y, Yamazaki S, Sanada S, Asano Y, Ishibashi-Ueda H, Takashima S, Minamino T, Asanuma H, Mochizuki N, Kitakaze M.
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Journal Title
Am J Physiol Heart Circ Physiol.
Volume: 304
Pages: H1361-9
DOI
Related Report
Peer Reviewed
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[Journal Article] Liposomal amiodarone augments anti-arrhythmic effects and reduces hemodynamic adverse effects in an ischemia/reperfusion rat model.2013
Author(s)
Takahama H, Shigematsu H, Asai T, Matsuzaki T, Sanada S, Fu HY, Okuda , Yamato M, Asanuma H, Asano Y, Asakura M, Oku N, Komuro I, Kitakaze M, Minamino T.
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Journal Title
Cardiovasc Drugs Ther.
Volume: 27
Pages: 125-32
DOI
Related Report
Peer Reviewed
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[Journal Article] Hyponatremia and in-hospital mortality in patients admitted for heart failure (from the ATTEND registry).2013
Author(s)
Sato N, Gheorghiade M, Kajimoto K, Munakata R, Minami Y, Mizuno M, Aokage T, Asai K, Sakata Y, Yumino D, Mizuno K, Takano T; ATTEND Investigators.
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Journal Title
Am J Cardiol.
Volume: 111
Pages: 1019-25
DOI
Related Report
Peer Reviewed
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[Journal Article] H(2) mediates cardioprotection via involvements of K(ATP) channels and permeability transition pores of mitochondria in dogs.2012
Author(s)
Yoshida A, Asanuma H, Sasaki H, Sanada S, Yamazaki S, Asano Y, Shinozaki Y, Mori H, Shimouchi A, Sano M, Asakura M, Minamino T, Takashima S, Sugimachi M, Mochizuki N, Kitakaze M.
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Journal Title
Cardiovasc Drugs Ther.
Volume: 26
Pages: 217-26
DOI
Related Report
Peer Reviewed
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[Book] 医学のあゆみ2013
Author(s)
朝野仁裕、小室一成.
Total Pages
425-421
Publisher
医歯薬出版株式会社
Related Report
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