| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Gut-lung axis may play a role in the development of chronic obstructive pulmonary disease (COPD) and it is assumed that the deterioration in gut environment is associated with the development of comorbidities of COPD. In the present study, we found that the deterioration in gut environment caused by discontinuous feeding with fiber-free diet accelerates not only emphysema but also malnutrition and osteoporosis by cigarette smoke in rats. In addition, it suggests that the changes in the gut environment by the synbiotics may attenuate not only pulmonary emphysema but also osteoporosis induced by cigarette smoke in rats. Feasibility of the synbiotics was confirmed and the intervention study in patients with COPD is ongoing.
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