Clarification of the mechanism of iron metabolism in diabetic nephropathy and search of therapeutic factor for anti-diabetic nephropathy
| Project/Area Number |
24591203
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | The University of Tokushima |
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Principal Investigator |
IKEDA Yasumasa 徳島大学, ヘルスバイオサイエンス研究部, 准教授 (60432754)
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| Co-Investigator(Renkei-kenkyūsha) |
TAJIMA Soichiro 徳島大学, 病院, 薬剤師 (10579460)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 鉄 / 糖尿病腎症 / 酸化ストレス / 腎線維化 / 血管内皮 / 糖尿病性腎症 / NADPH oxidase |
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| Outline of Final Research Achievements |
In the present study, we analyzed the protective effects of dietary iron restriction against diabetic nephropathy. Male db/db mice were divided into 2 groups and fed a normal diet (ND) or a low iron diet (LID), and male db/m mice with ND were employed as control. Increased urinary albumin excretion was observed in db/db mice with ND, and this was suppressed in db/db mice with LID. The db/db mice with ND had increased glomerular size, mesangial expansion and extracellular matrixes deposition compared to the LID group, which were decreased by LID. Increased renal oxidative stress observed in the ND db/db mice were diminished in the LID group. Renal expression of ferroportin and ferritin heavy chain, as well as serum iron concentration and urinary iron excretion, were increased in db/db mice compared to db/m mice. Taken together, iron reduction exerts a preventive action against diabetic nephropathy, and abnormal iron metabolism was observed in diabetic kidney.
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Report
(4 results)
Research Products
(45 results)
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[Journal Article] Angiotensin II alters the expression of duodenal iron transporters, hepatic hepcidin, and body iron distribution in mice.2015
Author(s)
Tajima S, Ikeda Y, Enomoto H, Imao M, Horinouchi Y, Izawa-Ishizawa Y, Kihira Y, Miyamoto L, Ishizawa K, Tsuchiya K, Tamaki T.
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Journal Title
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Iron chelation by deferoxamine prevents renal interstitial fibrosis in mice with unilateral ureteral obstruction.2014
Author(s)
Ikeda Y, Ozono I, Tajima S, Imao M, Horinouchi Y, Izawa-Ishizawa Y, Kihira Y, Miyamoto L, Ishizawa K, Tsuchiya K, Tamaki T.
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Journal Title
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Overexpressed HIF-2α in Endothelial Cells Promotes Vascularization and Improves Random Pattern Skin Flap Survival.2014
Author(s)
Morimoto A, Tomita S, Imanishi M, Shioi G, Kihira Y, Izawa-Ishizawa Y, Takaku M, Hashimoto I, Ikeda Y, Nakanishi H, Tamaki T.
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Journal Title
Plast Reconstr Surg Glob Open
Volume: 7
Issue: 4
Pages: e132-e132
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Deletion of hypoxia-inducible factor-1α in adipocytes enhances glucagon-like peptide-1 secretion and reduces adipose tissue inflammation.2014
Author(s)
Kihira Y, Miyake M, Hirata M, Hoshina Y, Kato K, Shirakawa H, Sakaue H, Yamano N, Izawa-Ishizawa Y, Ishizawa K, Ikeda Y, Tsuchiya K, Tamaki T, Tomita S.
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Journal Title
Related Report
Peer Reviewed / Open Access
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[Journal Article] Nitrosonifedipine ameliorates the progression of type 2 diabetic nephropathy by exerting antioxidative effects.2014
Author(s)
Ishizawa K, Izawa-Ishizawa Y, Yamano N, Urushihara M, Sakurada T, Imanishi M, Fujii S, Nuno A, Miyamoto L, Kihira Y, Ikeda Y, Kagami S, Kobori H, Tsuchiya K, Tamaki T.
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Journal Title
PLoS One.
Volume: 9(1)
Issue: 1
Pages: 86335-86335
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Androgen receptor promotes sex-independent angiogenesis in response to ischemia and is required for activation of vascular endothelial growth factor receptor signaling2013
Author(s)
Yoshida S, Aihara K, Ikeda Y, Sumitomo-Ueda Y, Uemoto R, Ishikawa K, Ise T, Yagi S, Iwase T, Mouri Y, Sakari M, Matsumoto T, Takeyama K, Akaike M, Matsumoto M, Sata M, Walsh K, Kato S, Matsumoto T.
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Journal Title
Circulation
Volume: 128
Issue: 1
Pages: 60-71
DOI
Related Report
Peer Reviewed
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[Presentation] ビリルビンの血管新生促進作用の検討2015
Author(s)
池田 康将, 金井 佑亮, 堀ノ内 裕也, 石澤 有紀, 木平 孝高, 宮本 理人, 石澤 啓介, 土屋 浩一郎, 玉置 俊晃
Organizer
第44回 日本心脈管作動物質学会
Place of Presentation
高松センタービル （香川県高松市）
Year and Date
2015-02-06
Related Report
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[Presentation] 鉄による骨格筋萎縮メカニズムの検討2014
Author(s)
池田 康将, 今尾 瑞季, 佐藤 明穂, 堀ノ内 裕也, 石澤 有紀, 木平 孝高, 宮本 理人, 石澤 啓介, 土屋 浩一郎, 玉置 俊晃
Organizer
日本鉄バイオサイエンス学会 第38回学術集会
Place of Presentation
仙台国際センター（宮城県仙台市）
Year and Date
2014-09-06
Related Report
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[Presentation] フェリチンの炎症惹起作用
Author(s)
池田 康将, 田島 壮一郎, 今尾 瑞季, 堀ノ内 裕也, 石澤 有紀, 木平 孝高, 石澤 啓介, 土屋 浩一郎, 玉置 俊晃
Organizer
第37回日本鉄バイオサイエンス学会
Place of Presentation
JA 共済ビル（東京都）
Related Report
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