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Search for unknown thyroid stem cells - Can the thyroid regenerate? -

Research Project

Project/Area Number 24591371
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Endocrinology
Research InstitutionWakayama Medical University

Principal Investigator

OZAKI Takashi  和歌山県立医科大学, 医学部, 非常勤講師 (40351390)

Co-Investigator(Kenkyū-buntansha) MURAGAKI Yasuteru  和歌山県立医科大学, 医学部, 教授 (40190904)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords甲状腺 / 再生 / 幹細胞 / 癌細胞 / マイクロ波 / 癌 / 脱分化
Outline of Final Research Achievements

To examine thyroid regeneration, the presence or absence of stem cells (or cancer stem cells) required for the regeneration was examined. The Oct4 gene is an important stem cell/cancer stem cell factor. We established a method to induce Oct4 gene expression using microwave irradiation, demonstrating morphologically and molecularly that cancer stem cells may be induced from anaplastic thyroid cancer.
Microwave irradiation (2,450 MHz, 47℃) morphologically altered anaplastic thyroid cancer cells and reduced cell adhesion (spheroid formation). In addition, Oct4 gene expression was significantly increased, suggesting the presence of thyroid (cancer) stem cells. The presence of (cancer) stem cells suggests the future possibility of thyroid regeneration.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (26 results)

All 2015 2014 2013 2012 Other

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (13 results) Remarks (1 results)

  • [Journal Article] Expression of stanniocalcin 1 in thyroid side population cells and thyroid cancer cells.2015

    • Author(s)
      2.Hayase S, Sasaki Y, Matsubara T, Seo D, Miyakoshi M, Murata T, Ozaki T, Kakudo K, Kumamoto K, Ylaya K, Cheng SY, Thorgeirsson SS, Hewitt SM, Ward JM, Kimura S.
    • Journal Title

      Thyroid

      Volume: 25 Issue: 4 Pages: 425-36

    • DOI

      10.1089/thy.2014.0464

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Up-regulation of urinary-type plasminogen activator correlates with high-risk papillary thyroid carcinoma with BRAF(V600E) mutation and its possible molecular mechanism.2014

    • Author(s)
      1.Wakasa T, Li Y, Bai Y, Liu Z, Ozaki T, Mori I, Miyauchi A, Kakudo K, Nakamura M.
    • Journal Title

      Pathol Res Pract.

      Volume: 210 Issue: 11 Pages: 733-8

    • DOI

      10.1016/j.prp.2014.06.025

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intrathyroid epithelial thymoma (ITET) and carcinoma showing thymus-like differentiation (CASTLE): CD5-positive neoplasms mimicking squamous cell carcinoma of the thyroid.2013

    • Author(s)
      Kakudo K, Bai Y, Ozaki T, Homma K, Ito Y, Miyauchi A
    • Journal Title

      Histol Histopathol

      Volume: 28 Pages: 543-56

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Construction of web-based remote diagnosis system using virtual slide for routine pathology slides of the rural hospital in Japan.2013

    • Author(s)
      Mori I, Ozaki T, Muragaki Y, Ibata T, Ueda H, Shinagawa T, Osamura Y.
    • Journal Title

      Diagnostic Pathology

      Volume: 8

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Uterine damage in swine following uterine artery embolization: comparison among gelatin sponge particles and two concentrations of N-butyl cyanoacrylate.2013

    • Author(s)
      Sonomura T, Kawai N, Ikoma A, Minamiguchi H, Ozaki T, Kishi K, Sanda H, Nakata K, Nakai M, Muragaki Y, Sato M.
    • Journal Title

      Jpn J Radiol

      Volume: 31 Pages: 685-92

    • NAID

      50008985890

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Thyroid regeneration: characterization of clear cells after partial thyroidectomy.2012

    • Author(s)
      Ozaki T, Matsubara T, Seo D, Okamoto M, Nagashima K, Sasaki Y, Hayase S, Murata T, Liao XH, Hanson J, Rodriguez-Canales J, Thorgeirsson SS, Kakudo K, Refetoff S, Kimura S.
    • Journal Title

      Endocrinology

      Volume: 153 Issue: 5 Pages: 2514-25

    • DOI

      10.1210/en.2011-1365

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Classification of thyroid follicular cell tumors: with special reference to borderline lesions.2012

    • Author(s)
      Kakudo K, Bai Y, Liu Z, Li Y, Ito Y, Ozaki T.
    • Journal Title

      Endocr J

      Volume: 59 Pages: 1-12

    • NAID

      10030392683

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Encapsulated papillary thyroid carcinoma, follicular variant: a misnomer.2012

    • Author(s)
      Kakudo K, Bai Y, Liu Z, Ozaki T.
    • Journal Title

      Pathol Int

      Volume: 62 Issue: 3 Pages: 155-60

    • DOI

      10.1111/j.1440-1827.2011.02773.x

    • NAID

      10031185183

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] IgG4-related disease of the thyroid glands.2012

    • Author(s)
      Kakudo K, Li Y, Taniguchi E, Mori I, Ozaki T, Nishihara E, Matsuzuka F, Miyauchi A.
    • Journal Title

      Endocr J

      Volume: 59 Pages: 273-81

    • NAID

      10030749245

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Distinct histopathological features of Hashimoto's thyroiditis with respect to IgG4-related disease.2012

    • Author(s)
      Li Y, Zhou G, Ozaki T, Nishihara E, Matsuzuka F, Bai Y, Liu Z, Taniguchi E, Miyauchi A, Kakudo K.
    • Journal Title

      Mod Pathol

      Volume: 25 Pages: 1086-97

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cytological features of well-differentiated tumors of uncertain malignant potential: Indeterminate cytology and WDT-UMP.2012

    • Author(s)
      Nishigami K, Liu Z, Taniguchi E, Koike E, Ozaki T, Mori I, Kakudo K.
    • Journal Title

      Endocr J

      Volume: 59 Pages: 483-7

    • NAID

      10030816746

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A novel oncogenic pathway by TLS-CHOP involving repression of MDA-7/IL-24 expression.2012

    • Author(s)
      Oikawa K, Tanaka M, Itoh S, Takanashi M, Ozaki T, Muragaki Y, Kuroda M.
    • Journal Title

      Br J Cancer

      Volume: 106 Pages: 1976-9

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 甲状腺未分化癌細胞株に対するマイクロ波効果の検討2014

    • Author(s)
      尾崎敬,田伏克惇,渡邊雄也, 孫玉静,下角あい子,中西雅子, 佐藤冬樹,及川恒輔,覚道健一,村垣泰光
    • Organizer
      第42回和歌山悪性腫瘍研究会
    • Place of Presentation
      和歌山市
    • Year and Date
      2014-12-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] 粘液型脂肪肉腫特異的キメラがんタンパクTLS-CHOPの下流分子の検討2014

    • Author(s)
      4.及川恒輔,田中正視,高梨正勝,尾崎敬,黒田雅彦,村垣泰光
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 甲状腺未分化癌細胞株に対する非熱的マイクロ波効果の検討2014

    • Author(s)
      尾﨑敬,田伏克惇,渡邊雄也,覚道健一,孫玉静,下角あい子,中西雅子,佐藤冬樹,及川恒輔,村垣泰光
    • Organizer
      第33回Microwave Surgery研究会
    • Place of Presentation
      高槻市(大阪府)
    • Year and Date
      2014-09-12 – 2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] マイクロ波の非熱性効果による細胞死誘導メカニズムに関する基礎的研究(2)2014

    • Author(s)
      浅野麻実子,田中智,坂口実,高岡昌徳,平田雅彦,山口敬子,松村人志,藤田芳一,田伏克惇,仲谷博文,尾崎敬
    • Organizer
      第33回Microwave Surgery研究会
    • Place of Presentation
      高槻市(大阪府)
    • Year and Date
      2014-09-12 – 2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] 甲状腺は再生する臓器か?-マウス動物実験から検討-2013

    • Author(s)
      尾﨑敬,覚道健一,Gui Ting,Sun Yujing,下角あい子,伊藤俊治,及川恒輔,村垣泰光,木村芝生子
    • Organizer
      第86回日本内分泌学会学術総会
    • Place of Presentation
      仙台市
    • Related Report
      2013 Research-status Report
  • [Presentation] 甲状腺癌細胞株に対する非熱的マイクロ波効果の検討2013

    • Author(s)
      尾崎敬,覚道健一,Gui Ting,Sun Yujing,下角あい子,伊藤俊治,及川恒輔,田伏克惇,村垣泰光
    • Organizer
      第102 回日本病理学会総会
    • Place of Presentation
      札幌市
    • Related Report
      2013 Research-status Report
  • [Presentation] 病理画像情報のデジタル化と、実地診断への応用2013

    • Author(s)
      森一郎,尾崎敬,村垣泰光,長村義之
    • Organizer
      第102 回日本病理学会総会
    • Place of Presentation
      札幌市
    • Related Report
      2013 Research-status Report
  • [Presentation] マイクロ波効果-基礎的研究-甲状腺癌細胞株に対する非熱的マイクロ波効果の検討2013

    • Author(s)
      尾﨑敬,田伏克惇,孫玉静,下角あい子,伊藤俊治,及川恒輔,覚道健一,村垣泰光
    • Organizer
      第32回Microwave Surgery研究会
    • Place of Presentation
      東京都
    • Related Report
      2013 Research-status Report
  • [Presentation] マイクロ波効果-基礎的研究-マイクロ波の非熱性効果による細胞死誘導メカニズムに関する基礎的検討2013

    • Author(s)
      浅野麻実子,田中智,坂口実,高岡昌徳,平田雅彦,山口敬子,松村人志,藤田芳一,田伏克惇,中谷博文,田浦映恵,尾﨑敬
    • Organizer
      第32回Microwave Surgery研究会
    • Place of Presentation
      東京都
    • Related Report
      2013 Research-status Report
  • [Presentation] 甲状腺癌細胞株に対する非熱的マイクロ波効果の検討2013

    • Author(s)
      尾﨑敬, Sun Yujing, 下角あい子, 伊藤俊治, 及川恒輔, 村垣泰光, 田伏克惇, 覚道健一
    • Organizer
      第81回和歌山医学会総会
    • Place of Presentation
      和歌山市
    • Related Report
      2013 Research-status Report
  • [Presentation] 粘液型脂肪肉腫特異的キメラがんタンパクTLS-CHOPによる多段階発がん機構の検討2013

    • Author(s)
      及川恒輔, 伊藤俊治, 田中正視, 高梨正勝, 孫 玉静, 尾﨑敬, 黒田雅彦, 村垣泰光
    • Organizer
      第36回日本分子生物学会
    • Place of Presentation
      神戸市
    • Related Report
      2013 Research-status Report
  • [Presentation] 粘液型脂肪肉腫特異的キメラがんタンパクTLS-CHOPによる発がん分子メカニズム2013

    • Author(s)
      及川恒輔, 伊藤俊治, 孫 玉静, 下角あい子, 尾﨑敬, 村垣泰光.
    • Organizer
      第81回和歌山医学会総会
    • Place of Presentation
      和歌山市
    • Related Report
      2013 Research-status Report
  • [Presentation] 甲状腺は再生する臓器か?-マウス動物実験から検討-2013

    • Author(s)
      尾崎敬,覚道健一,伊藤俊治,及川恒輔,村垣泰光,木村芝生子
    • Organizer
      第86回日本内分泌学会学術総会
    • Place of Presentation
      仙台 (仙台国際センター)
    • Related Report
      2012 Research-status Report
  • [Remarks] 和歌山県立医科大学 第一病理学教室 ホームページ

    • URL

      http://www.wakayama-med.ac.jp/dept/igakubu/160417/index.html

    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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