Analysis of clonal hierarchy and microenvironment of the tumor developed in the mouse mantle cell lymphoma model

• Project/Area Number: 24591391
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hematology
• Research Institution: Kyoto University
• Principal Investigator: NISHIKORI Momoko 京都大学, 医学(系)研究科(研究院), 助教 (60378635)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 悪性リンパ腫 / マウスモデル / BCL2 / CyclinD1 / Cyclin D1

Outline of Final Research Achievements

Malignant lymphoma is classified into many histologic subtypes. They exhibit their own biological features that are shaped during their differentiation and maturation steps of lymphocytes in vivo. In this study, we have generated mouse lymphoma models that are triggered by CCND1 and BCL2 overexpression, and compared phenotypic and genotypic features of these tumors. We have found several important biological mechanisms on lymphoma histology determination that are considered common to humans.

Research Products

• [Journal Article] Ki-67 is a strong predictor of central nervous system relapse in patients with mantle cell lymphoma (MCL). (2015)
  • Author(s): Chihara D, Asano N, Ohmachi K, Nishikori M, Okamoto M, Sawa M, Sakai R, Okoshi Y, Tsukamoto N, Yakushijin Y, Nakamura S, Kinoshita T, Ogura M, Suzuki R.
  • Journal Title: Ann Oncol. Volume: 未定 Issue: 5 Pages: 966-973
  • DOI: 10.1093/annonc/mdv074
  • Peer Reviewed / Open Access
• [Journal Article] Increased number of peripheral CD8+ T cells but not eosinophils is associated with late-onset skin reactions caused by bendamustine. (2015)
  • Author(s): Nishikori M, Kitano T, Kobayashi M, Hishizawa M, Kitawaki T, Kondo T, Yamashita K, Kawabata H, Kadowaki N, Takei Y, Haga H, Takaori-Kondo A.
  • Journal Title: Int J Hematol. Volume: 未定 Issue: 1 Pages: 53-58
  • DOI: 10.1007/s12185-015-1791-3
  • NAID: 120005674658
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Molecular Pathogenesis of Follicular Lymphoma (2014)
  • Author(s): Kishimoto W, Nishikori M.
  • Journal Title: Journal of Clinical and Experimental Hematopathology Volume: 54 Issue: 1 Pages: 23-30
  • DOI: 10.3960/jslrt.54.23
  • NAID: 130004886472
  • ISSN: 1346-4280, 1880-9952
  • Peer Reviewed / Open Access
• [Journal Article] A Clinical, Pathological and Genetic Characterization of Methotrexate-Associated Lymphoproliferative Disorders. (2014)
  • Author(s): Yamakawa N, Fujimoto M, Kawabata D, Terao C, Nakashima R, Imura Y, Yukawa N, Yoshifuji H, Ohmura K, Fujii T, Yurugi K, Miura Y, Maekawa T, Saji H, Matsuda F, Haga H, Mimori T
  • Journal Title: J Rheumatol Volume: 41 Issue: 2 Pages: 293-299
  • DOI: 10.3899/jrheum.130270
  • Peer Reviewed
• [Journal Article] Primary peripheral T-cell lymphoma, not otherwise specified of the thyroid with autoimmune thyroiditis. (2013)
  • Author(s): Yoshida N, et al
  • Journal Title: Br J Haematol. Volume: 161 Issue: 2 Pages: 214-223
  • DOI: 10.1111/bjh.12255
  • Peer Reviewed
• [Journal Article] B細胞リンパ腫における染色体転座の意義 (2013)
  • Author(s): 錦織 桃子
  • Journal Title: 臨床血液 Volume: 54 Pages: 234-241
  • NAID: 10031196323
• [Presentation] Expression of Tim-1 and Its Pathogenetic Role in Primary CNS Lymphoma. (2014)
  • Author(s): Kishimoto W, Nishikori M, Arima H, Shirakawa K, Kitawaki T, Takaori-Kondo A.
  • Organizer: 56th ASH Annual Meeting and Exposition
  • Place of Presentation: サンフランシスコ
  • Year and Date: 2014-12-06 – 2014-12-09
• [Presentation] Ki-67 Is a Strong Predictor for Central Nervous System Relapse in Patients with Mantle Cell Lymphoma (MCL). (2014)
  • Author(s): Chihara D, Asano N, Ohmachi K, Nishikori M, Okamoto M, Sawa M, Sakai R, Okoshi Y, Tsukamoto N, Yakushijin Y, Nakamura S, Kinoshita T, Ogura M, Suzuki R.
  • Organizer: 56th ASH Annual Meeting and Exposition
  • Place of Presentation: サンフランシスコ
  • Year and Date: 2014-12-06 – 2014-12-09
• [Presentation] Expression of AID in neoplastic cells correlates with disease severity and worse outcome of DLBCL. (2014)
  • Author(s): Arima H, Fujimoto M, Kishimoto W, Nishikori M, Hishizawa M, Kitano T, Kondo T, Kadowaki N, Haga H, Akifumi-Takaori K.
  • Organizer: 第76回日本血液学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2014-10-31 – 2014-11-02
• [Presentation] Expression of Tim-1 and its pathogenetic role in primary CNS lymphoma. (2014)
  • Author(s): Kishimoto W, Nishikori M, Arima H, Shirakawa K, Kitawaki T, Takaori-Kondo A.
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-25 – 2015-09-27
• [Presentation] B細胞性リンパ腫の臨床像と分子病態 (2014)
  • Author(s): 錦織 桃子
  • Organizer: 第54回日本リンパ網内系学会総会
  • Place of Presentation: 山形
  • Year and Date: 2014-06-20
  • Invited
• [Presentation] The isotype of the B-cell receptor in patients with follicular lymphoma. (2014)
  • Author(s): 岸本渉、田嶌政治、有馬浩史、錦織桃子、北野俊行、高折晃史
  • Organizer: 第54回日本リンパ網内系学会総会
  • Place of Presentation: 山形
  • Year and Date: 2014-06-19 – 2014-06-21
• [Presentation] 低悪性度非ホジキンリンパ腫治療の新展開． シンポジウム2 ：造血器腫瘍の治療法の新展開 (2013)
  • Author(s): 錦織 桃子
  • Organizer: 第11回日本臨床腫瘍学会学術集会
  • Place of Presentation: 仙台
  • Invited
• [Presentation] B細胞リンパ腫における染色体転座の意義 (2013)
  • Author(s): 錦織 桃子
  • Organizer: 第75回日本血液学会学術集会
  • Place of Presentation: 札幌
  • Invited
• [Presentation] 薬剤性心腎機能障害とCMV網膜炎を伴った難治性濾胞性リンパ腫に対し臍帯血ミニ移植を実施し寛解を維持している一例 (2013)
  • Author(s): 河田岳人、錦織桃子、志村和穂、北野俊行、近藤忠一、門脇則光、高折晃史
  • Organizer: 第53回日本リンパ網内系学会総会
  • Place of Presentation: 京都
• [Presentation] Allogeneic HSCT for recurrent/refractory follicular lymphoma in a single institution. (2013)
  • Author(s): Tashima M, Kondo T, Kitano T, Maeda T, Nishikori M, Yamashita K, Kadowaki N, Takaori-Kondo A.
  • Organizer: 第75回日本血液学会学術集会
  • Place of Presentation: 札幌
• [Presentation] The isotype of the B-cell receptor predicts survival of patients with DLBCL treated with R-CHOP. (2013)
  • Author(s): Arima H. Kitano T, Maeda T, Nishikori M, Kondo T, Kadowaki N, Takaori-Kondo A.
  • Organizer: 第75回日本血液学会学術集会
  • Place of Presentation: 札幌
• [Presentation] Establishment of a mouse model for mantle cell lymphoma. (2012)
  • Author(s): 岸本渉、錦織桃子、田嶌政治、山本玲、坂井智美、都築忍、瀬戸加大、高折晃史
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: 札幌
• [Presentation] A murine model for eludicating the mechanism of lymphoma subtype determination. (2012)
  • Author(s): 錦織桃子、田嶌政治、岸本渉、高折晃史
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: 札幌
  • Invited
• [Presentation] Deregulation of CCND1 or BCL2 in immature B-cell stage determines the resulting lymphoma histology. (2012)
  • Author(s): 田嶌政治、錦織桃子、岸本渉、山本玲、坂井智美、都築忍、瀬戸加大、高折晃史
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 京都
• [Presentation] Deregulation of CCND1 or BCL2 in immature B-cell stage determines the resulting lymphoma histology. (2012)
  • Author(s): 田嶌政治、錦織桃子、岸本渉、山本玲、坂井智美、大森勝之、都築忍、瀬戸加大、高折晃史
  • Organizer: The 54th ASH Annual Meeting and Exposition
  • Place of Presentation: 米国 アトランタ
• [Remarks] 京都大学大学院医学研究科 血液・腫瘍内科学 リンパ腫研究
  • URL: http://www.kuhp.kyoto-u.ac.jp/̃hemonc/research/lymphoma.html
• [Remarks] 京都大学大学院医学研究科 血液・腫瘍内科学 リンパ腫研究
  • URL: http://www.kuhp.kyoto-u.ac.jp/~hemonc/research/lymphoma.html