Identification of human regulatory B cells and their role in autoimmune diseases
Project/Area Number |
24591450
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
膠原病・アレルギー・感染症内科学
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Research Institution | Kyushu University |
Principal Investigator |
NIIRO HIROAKI 九州大学, 大学病院, 准教授 (20380636)
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Co-Investigator(Kenkyū-buntansha) |
AKASHI Koichi 九州大学, 医学研究院, 教授 (80380385)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 自己免疫疾患 / B細胞 / 免疫学 |
Outline of Final Research Achievements |
In the present study, we showed that IL-10-producing regulatory B cells (Bregs) are predominantly induced in human IgM-memory B cell subsets in the peripheral blood, and also showed that Blimp-1, a master regulator of plasma cell differentiation, plays a critical role in Breg induction. Patients with SLE, a prototypic autoimmune disease, exhibited defective Breg function mainly via impaired induction of Blimp-1.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Periostin promotes the generation of fibrous membranes in proliferative vitreoretinopathy2014
Author(s)
Ishikawa K, Yoshida S, Nakao S, Nakama T, Kita T, Asato R, Sassa Y, Arita R, Miyazaki M, Enaida H, Oshima Y, Murakami N, Niiro H, Ono J, Matsuda A, Goto Y, Akashi K, Izuhara K, Kudo A, Kono T, Hafezi-Moghadam A, Ishibashi T.
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Journal Title
FASEB J
Volume: 28
Issue: 1
Pages: 131-142
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Charateristics of MPO-ANCA-positive granulomatosis with polyangiitis: a retrospective multi-center study in Japan.2014
Author(s)
Ono N, Niiro H, Ueda A, Sawabe T, Nishizaka H, Furugo I, Yoshizawa S, Yoshizawa S, Tsukamoto H, Kiyohara C, Tada Y, Horiuchi
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Journal Title
Rheumatol Int
Volume: 35
Issue: 3
Pages: 555-559
DOI
Related Report
Peer Reviewed
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[Journal Article] The cytotoxic effects of certolizumab pegol and golimumab mediated by transmembrane tumor necrosis factor α.2013
Author(s)
Ueda N, Tsukamoto H, Mitoma H, Ayano M, Tanaka A, Ohta S, Inoue Y, Arinobu Y, Niiro H, Akashi K, Horiuchi T.
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Journal Title
Inflamm Bowel Dis.
Volume: 19
Issue: 6
Pages: 1224-1231
DOI
Related Report
Peer Reviewed
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[Journal Article] Serum progranulin levels are elevated in patients with systemic lupus erythematosus, reflecting disease activity.2012
Author(s)
Tanaka A, Tsukamoto H, Mitoma H, Kiyohara C, Ueda N, Ayano M, Ohta SI, Inoue Y, Arinobu Y, Niiro H, Horiuchi T, and Akashi K
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Journal Title
Arthritis Res Ther
Volume: 14
Related Report
Peer Reviewed
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[Presentation] Elucidation of melecular mechanisms of Breg induction in autoimmune diseases2014
Author(s)
Shun-ichiro Ota, Hiroaki Niiro, Naoko Ueki, Yuri Hirosaki, Hirofumi Tsuzuki, Kumiko Noda, Siamak Jabbarzadeh-Tabrizi,Atsushi Tanaka, Hiroki Mitoma, Yojiro Arinobu, Mitsuteru Akahoshi, Hiroshi Tsukamoto, and Koichi Akashi.
Organizer
ACR annual meeting 2014
Place of Presentation
Boston, MA, USA
Year and Date
2014-11-18
Related Report
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