| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
To investigate the pathogenesis of pediatric onset gastrointestinal diseases, such as food protein-induced proctocolitis (FPIP), neonatal transient eosinophilic colitis (NTEC), Crohn’s disease (CD), and ulcerative colitis (UC), we examined the mucosal expression of inflammatory signals using microarray, RT-PCR, and immunohistochemical analysis. Enhanced expression of IL-6, CCL11, and CXCL13 was confirmed in both NTEC and FPIP. Mucosal infiltration of CD3- and IgA- but not IgE-positive cells was confirmed in both. Studies with CD and UC revealed that the expression of CXCL9, 10, 11 and MMP-1, -3, -7, -10 was significantly enhanced in active phase of pediatric CD and UC, respectively. Meanwhile, enhanced expression of CXCL13 was confirmed among these diseases suggested that IgA synthesis targeting multiple antigens is an important task for the mucosal immune systems during infancy since CXCL13 is a chemokine related to lymphoid follicle formation leading to IgA synthesis.
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