Study of the glutamate excitotoxicity in the hippocampus with Alzheimer's disease
Project/Area Number |
24591697
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Psychiatric science
|
Research Institution | University of Tsukuba |
Principal Investigator |
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | アルツハイマー病 / 神経細胞変性 / 神経科学 / 認知症 / ブチリルコリンエステラーゼ / ユビキリン / アセチルコリン伝達系 / 海馬 / 神経変性 |
Outline of Final Research Achievements |
The postmortem study examined immunohistochemical localization and distribution of ubiquilin (UBL) and butyrylcholinesterase (BChE), in the hippocampus from Alzheimer’s disease (AD) dementia cases. All Braak III-IV and the majority of Braak V-VI AD cases had markedly increased UBL immunoreactivity in the nucleoplasm of CA2/3, CA4, and dentate granular neurons. Compared to controls, AD cases had greater BChE immunoreactivity in hippocampal neurons and neuropil, most prominently in CA2/3 pyramidal neurons and stratum oriens. These results suggest that the prominent upregulation of ubiquilin and BChE activity in CA2/3, the region generally considered more resistant to pathology, could reflect a novel compensatory mechanism.
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Report
(4 results)
Research Products
(1 results)