| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
The postmortem study examined immunohistochemical localization and distribution of ubiquilin (UBL) and butyrylcholinesterase (BChE), in the hippocampus from Alzheimer’s disease (AD) dementia cases. All Braak III-IV and the majority of Braak V-VI AD cases had markedly increased UBL immunoreactivity in the nucleoplasm of CA2/3, CA4, and dentate granular neurons. Compared to controls, AD cases had greater BChE immunoreactivity in hippocampal neurons and neuropil, most prominently in CA2/3 pyramidal neurons and stratum oriens. These results suggest that the prominent upregulation of ubiquilin and BChE activity in CA2/3, the region generally considered more resistant to pathology, could reflect a novel compensatory mechanism.
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