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Study of clinical and biological differences between Hoarding Disorder and Obsessive-Compulsive Disorder

Research Project

Project/Area Number 24591719
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionKyushu University

Principal Investigator

NAKAO TOMOHIRO  九州大学, 大学病院, 講師 (50423554)

Co-Investigator(Kenkyū-buntansha) SANEMSTSU Hirokuni  九州大学, 大学病院, 助教 (30588116)
YOSHIURA Takashi  鹿児島大学, 医歯(薬)学総合研究科, 教授 (40322747)
HIWARASHI Akio  九州大学, 大学病院, 助教 (30444855)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsOCD / ためこみ / Hoarding Disorder(HD) / VBM / 画像解析 / 疫学調査 / HD / 溜め込み
Outline of Final Research Achievements

Until the end of May 2015, 25 participants were conducted a structured interview. Of those participants, 17 cases met the diagnostic criteria of Hoarding Disorder(HD). The average age of HD patients were 43.6±13.5(21~73).
We assessed the severity of hoarding symptoms using CIRS. To investigate the correlation between gray matter volume and hoarding severity, we conducted one way analysis of variance using voxel-based morphometry among three groups(4 HD patients, 22 OCD patients, 10 healthy controls). We, however, could not find any significant differences among the three groups. In the correlation analysis using the hoarding scores of OCD patients, several candidate (visual association area, supramarginal gyrus, etc) sites have been found.In the present study, we cooud not find significant results by image analysis due to the small sample size of the hoarding patients. Reanalysis shoud be needed with larger hoarding samples.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (17 results)

All 2014 2013 2012

All Journal Article (5 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (7 results) Book (5 results)

  • [Journal Article] Biological heterogeneity of obsessive-compulsive disorder: A voxel-based morphometric study based on dimensional assessment.2014

    • Author(s)
      Okada K, Nakao T, Sanematsu H, Murayama K, Honda S, Tomita M, Togao O, Yoshiura T, Kanba S.
    • Journal Title

      Psychiatry Clin Neurosci.

      Volume: 印刷中 Issue: 7 Pages: 411-421

    • DOI

      10.1111/pcn.12269

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neurobiological model of obsessive-compulsive disorder: evidence from recent neuropsychological and neuroimaging findings.2014

    • Author(s)
      Nakao T, Okada K, Kanba S.
    • Journal Title

      Psychiatry Clin Neurosci.

      Volume: 68(8) Issue: 8 Pages: 587-605

    • DOI

      10.1111/pcn.12195

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 脳画像研究からみた強迫性障害のサブタイプ2013

    • Author(s)
      中尾智博
    • Journal Title

      精神科

      Volume: 23

    • Related Report
      2013 Research-status Report
  • [Journal Article] OCD の生物学的病態からみた難治性2013

    • Author(s)
      中尾智博
    • Journal Title

      精神神経誌

      Volume: 115 Pages: 981-989

    • Related Report
      2013 Research-status Report
  • [Journal Article] Differential neural network of checking versus washing symptoms in obsessive-compulsivedisorder2012

    • Author(s)
      Murayama K, Nakao T, Sanematsu H, Okada K, Yoshiura T, Tomita M, Masuda Y, Isomura K, Nakagawa A, Kanba S
    • Journal Title

      PROGRESS IN NEUROPSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

      Volume: 40巻 Pages: 160-6

    • DOI

      10.1016/j.pnpbp.2012.09.002

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 退院前訪問を繰り返し、居住スペースを確保し、退院となったためこみ症の一例2014

    • Author(s)
      安達利昭
    • Organizer
      第67回九州精神神経学会
    • Place of Presentation
      福岡
    • Year and Date
      2014-12-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] White Matter Structural Changes of Obsessive Compulsive disorder-from the aspect of Diffusion Tensor Imaging2014

    • Author(s)
      Okada K
    • Organizer
      第36回日本生物学的精神医学会年会
    • Place of Presentation
      奈良
    • Year and Date
      2014-09-29 – 2014-10-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] Hoarding(ため込み)と児童思春期に発症する精神疾患の関連についての疫学的研究2014

    • Author(s)
      桑野真澄
    • Organizer
      明治安田こころの健康財団2013年度研究助成 研究成果報告会
    • Place of Presentation
      東京
    • Year and Date
      2014-07-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] OCDの生物学的病態からみた難治性.2013

    • Author(s)
      中尾智博:
    • Organizer
      第109回日本精神神経学会総会シンポジウム「強迫性障害の難治性―その病態や基準、対応を考える」
    • Place of Presentation
      福岡
    • Related Report
      2013 Research-status Report
  • [Presentation] Correlation between regional gray matter volume and symptomatic dimension in OCD2012

    • Author(s)
      岡田佳代、村山桂太郎、實松寛晋、中尾智博
    • Organizer
      第34回日本生物学的精神医学会
    • Place of Presentation
      神戸
    • Related Report
      2012 Research-status Report
  • [Presentation] 強迫性障害の病態モデルと治療選択2012

    • Author(s)
      實松寛晋、中尾智博
    • Organizer
      第35回日本精神病理・精神療法学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] 強迫性障害の臨床と研究2012

    • Author(s)
      中尾智博
    • Organizer
      第3回琉球精神薬理研究会
    • Place of Presentation
      沖縄
    • Related Report
      2012 Research-status Report
  • [Book] 強迫性障害の早期徴候と治療・対応 水野雅文編;重症化させないための精神疾患の診方と対応2014

    • Author(s)
      中尾智博
    • Total Pages
      10
    • Publisher
      医学書院
    • Related Report
      2014 Annual Research Report
  • [Book] Hoarding(ため込み)と児童思春期に発症する精神疾患の関連についての疫学的研究2014

    • Author(s)
      中尾智博
    • Total Pages
      7
    • Publisher
      明治安田こころの健康財団 研究助成論文集
    • Related Report
      2014 Annual Research Report
  • [Book] 臨床精神医学2012

    • Author(s)
      中尾智博
    • Total Pages
      7
    • Publisher
      株式会社アークメディア
    • Related Report
      2012 Research-status Report
  • [Book] 強迫性障害のための身につける行動療法2012

    • Author(s)
      中尾智博
    • Total Pages
      11
    • Publisher
      岩崎学術出版社
    • Related Report
      2012 Research-status Report
  • [Book] 臨床精神医学2012

    • Author(s)
      村山桂太郎
    • Total Pages
      3
    • Publisher
      株式会社アークメディア
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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