| Project/Area Number |
24591921
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Aichi Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FUKUTOMI Takashi 愛知医科大学, 医学部, 教授 (30165302)
NAKANO Shogo 愛知医科大学, 医学部, 准教授 (20351108)
YOSHIDA Miwa 昭和大学, 医学部, 講師 (30556098)
KOUSAKA Jyunko 愛知医科大学, 医学部, 助手 (50440748)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | SHAP-HA複合体 / 腫瘍微小環境 / 腫瘍マーカー / 乳癌 / 酸化ストレス / ストレス / 細胞間質 / 乳癌間質組織 / 転移 |
|---|
| Outline of Final Research Achievements |
As it was considered that SHAP-HA complex might correlate with cancer micro-environment through the anti-oxidative stress system, we assessed the presence of glutathione in the breast cancer tissues. However, we failed to confirm the glutathione reaction concomitant with SHAP-HA complex. This indicates that SHAP-HA complex may play a role for creating cancer micro-environment through the other pass way. The serum concentration of SHAP-HA complex increased with the progress of the breast cancer, indicating that SHAP-HA complex could be applied as the tumor marker demonstrating the cancer stage.
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