| Project/Area Number |
24591945
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | The University of Tokushima |
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Principal Investigator |
TANGOKU Akira 徳島大学, ヘルスバイオサイエンス研究部, 教授 (10197593)
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| Co-Investigator(Kenkyū-buntansha) |
IMOTO Issei 徳島大学, 大学院ヘルスバイオサイエンス研究部, 教授 (30258610)
KAWAKAMI Yukikiyo 徳島大学, 病院, 特任講師 (00596249)
YOSHIDA Takahiro 徳島大学, 病院, 助教 (00380105)
FURUKITA Yoshihito 徳島大学, 大学院ヘルスバイオサイエンス研究部, 助教 (20563810)
NISHINO Takeshi 徳島大学, 病院, 医員 (80645193)
YAMAMOTO Yota 徳島大学, 病院, 助教 (50522273)
GOTO Masakazu 徳島大学, 病院, 特任助教 (00437659)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 食道癌 / 抗癌剤 / タキサン / 術前化学療法 / 抗癌剤感受性 |
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| Outline of Final Research Achievements |
The expression of ALDH1, CXCL12, CXCR4 and CXCR7 in the specimens from esophageal cancer were evaluated by immunohistochemistry and RT-PCR. These results were compared with the clinicopathological parameters and survival of the patients.
Results: High expression of CXCR4 with cytoplasmic and nuclear staining and CXCR7 were associated with cause-specific survival (CSS). The expression levels of messenger RNA (mRNA) of CXCR4 and CXCR7 were significantly increased in the tumor tissue compared with the normal esophageal tissue analysed by RT-PCR. The expression levels of mRNAs of CXCR4 was associated with CSS, and the expression levels of mRNA of CXCL12 and CXCR4 were associated with recurrence-free survival.
ALDH1 was associated with postoperative recurrence and prognosis. CD44 was found to be associated with postoperative recurrence and prognosis after chemotherapy. ALDH1-negative groups displayed better prognoses with operation only. ALDH1 did not influence on the effect of chemotherapy.
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