| Project/Area Number |
24592125
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kyoto University |
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Principal Investigator |
YOSHIDA Kazumichi 京都大学, 医学(系)研究科(研究院), 講師 (90598921)
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| Co-Investigator(Kenkyū-buntansha) |
ARAI Hidenori 京都大学, 医学(系)研究科(研究院), 教授 (60232021)
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| Co-Investigator(Renkei-kenkyūsha) |
OKADA Tomohisa 京都大学, 医学(系)研究科(研究院), 講師 (30321607)
SATO Yasufumi 東北大学, 加齢医学研究所, 教授 (50178779)
TAKAGI Yasushi 京都大学, 医学(系)研究科(研究院), 准教授 (40312227)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 動脈硬化 / 不安定プラーク / 頚動脈狭窄 / プラーク内出血 / 血管新生調節因子 / バソヒビン / 血管新生 / 分子イメージング |
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| Outline of Final Research Achievements |
It was demonstrated in this study that the expression level of novel angiogenic regulatory factor Vasohibin-1 was significantly higher in carotid atherosclerotic plaque than normal vascular endothelium. There was also significant positive correlation in the expression level between Vasohobin-1 and atherosclerosis-related inflammation markers such as ICAM-1 and VCAM-1. Immunohistochemical investigation revealed that Vasohibin-1 was predominantly expressed in the neovascular endothelium of carotid plaques. These findings strongly suggested the contribution of Vasohibin-1 in the destabilization mechanism of carotid atherosclerosis.
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