OPLL model mouse and mechanisms-de-ubiquitination leads to a posterior longitudinal ligament ossification breakthrough in proteomics
Project/Area Number |
24592215
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Orthopaedic surgery
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Research Institution | Kurume University |
Principal Investigator |
Tsuru Michiyo 久留米大学, 疾患プロテオミクス遺伝子治療, 講師 (90368887)
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Project Period (FY) |
2012-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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Keywords | 難病克服研究 / 後縦靭帯骨化症 / モデルマウス / プロテオミクス / 医薬品開発 / 難病 / 原因タンパク質 / 後縦靭帯骨化症モデルマウス / 治療製剤 / 創薬 / 治験 / プロテオーム / ノックアウトマウス / micro RNA / 脊柱靭帯骨化 / 糖尿病 / 再生医療 / 幹細胞 / POC / GCP / 有害事象 / 安全 / 臨床試験 |
Outline of Final Research Achievements |
In our nation, there are roughly 300 intractable diseases identified by the Ministry of Health, Labour and Welfare. Our study focuses on just one of these diseases; however, I am confident that it represents a breakthrough in our understanding of diseases whose causes were previously unknown. I strongly believe that our research method, proteomics, has much to offer in the fight against intractable diseases. I have devoted 15 years to demonstrating my theory through the identification and purification of disease-specific proteins, and the establishment of mouse models for such. This study has the potential to stamp out intractable diseases around the world; it is what researchers and patients alike have been hoping for.
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Report
(6 results)
Research Products
(15 results)
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[Presentation] 後縦靭帯骨化症のプロテオーム解析2015
Author(s)
津留美智代、小野睦、内田研造、戸山芳昭、永田見生
Organizer
第30回日本整形外科学会基礎学術集会
Place of Presentation
富山国際会議場
Year and Date
2015-10-22 – 2015-10-23
Related Report
Invited
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