Novel monitoring systems for consciousness and memory during anesthesia
| Project/Area Number |
24592293
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Kanazawa University |
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Principal Investigator |
YAMAMOTO Ken 金沢大学, その他部局等, 名誉教授 (90019638)
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| Co-Investigator(Kenkyū-buntansha) |
TSUBOKAWA Tsunehisa 東京慈恵会医科大学, 医学部, 教授 (80283109)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 脳磁図 / 脳波 / 意識 / 記憶 / 痛み / fMRI / 麻酔 |
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| Outline of Final Research Achievements |
To establish novel bedside monitoring methods for consciousness, memory and pain during anesthesia, we observed brain activities(BA) by magnetoencephalography (MEG), because MEG results are easily applied to electroencephalography (EEG). First, we observed BA during spontaneous sleeping, and found the foci of spindle, theta and delta waves. These data are available to develop the new EEG monitoring methods for consciousness in the future, but we could not observe BA under general anesthesia, because the ethics committee did not allow the experiment. Second, we tried to find the specific changes of BA by memory formation or recollection. We found some changes related to memory, while these changes were not specific,. Third, we observed the changes caused by pain. We used harmless ice pack as pain stimulator and found pain-specific changes in the amygdala, hypocampus, insula and anterior cingulate gyrus. Some of these BA would contribute to establishment of pain monitoring system.
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] Oxytocin attenuates feelings of hostility depending on emotional context and individuals' characteristics2012
Author(s)
Tetsu Hirosawa1, Mitsuru Kikuchi, Haruhiro Higashida, Eiichi Okumura, Sanae Ueno, Kiyomi Shitamichi, YukoYoshimura, Toshio Munesue, TsunehisaTsubokawa, Yasuhiro Haruta, Hideo Nakatani, Takanori Hashimoto, Yoshio Minabe
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Journal Title
Scientific Reports
Volume: (in press)
Issue: 1
Pages: 384-384
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Oxytocin attenuates feeling of hostility dependeng on emotional context and individuals’ characteristics2012
Author(s)
49. Hirosawa T., Kikuchi M., Higashida H., Okumura H., Ueno S., Shitamichi K., Yoshimura Y., Munesue T., Tsubokawa T., Haruta Y., Nakatani H., Hashimoto T., Minabe Y
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Journal Title
Scientific Reports
Volume: 384
Pages: 1-7
Related Report
Peer Reviewed
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[Journal Article] Language performance and auditory evoked fields in 2- to 5-year-old children2012
Author(s)
Yoshimura, Y., Kikuchi, M., Shitamichi, K., Ueno, S., Remijn, G.B., et al
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Journal Title
European Journal of Neuroscience
Volume: 35
Issue: 4
Pages: 644-650
DOI
Related Report
Peer Reviewed
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[Presentation] 術中覚醒記憶の予防と対処2014
Author(s)
坪川恒久
Organizer
第61回 日本麻酔科学会
Place of Presentation
横浜市 パシフィコ横浜
Year and Date
2014-05-15 – 2014-05-17
Related Report
Invited
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