Molecular mechanism of chronic pain via histone-dependent peripheral sensitization
| Project/Area Number |
24592356
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KISHIOKA Shiroh 和歌山県立医科大学, 医学部, 教授 (60137255)
KOBAYASHI Yuka 和歌山県立医科大学, 医学部, 助教 (20511562)
FUKAZAWA Yohji 関西医療大学, 保健医療学部, 准教授 (70336882)
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| Research Collaborator |
SAKAGUCHI Haruka
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 慢性疼痛 / 神経障害性疼痛 / ヒストン / マクロファージ / ケモカイン / エピジェネティクス / 炎症 / サイトカイン / CCL3 / フェノタイプ / CCL8 / MIP / VEGF |
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| Outline of Final Research Achievements |
We focused on the roles of histone, a nuclear protein, in molecular mechanisms of chronic pain. Immune cells including macrophages were accumulated in the injured nerves, and they produced pain-facilitating molecules such as chemokines. We found that these expressions were mediated by modification (acetylation and methylation) of histones. Moreover, macrophages were polarized into pain-facilitating phenotype by histone modification. We demonstrated that inhibition of these types of macrophages by pharmacological treatment was able to improve chronic pain. Taken together, histone modification in macrophages might be key machinery of chronic pain, and it will be candidate of novel therapeutic target.
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Report
(4 results)
Research Products
(35 results)
