| Project/Area Number |
24592401
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Nagoya City University |
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Principal Investigator |
KATO Toshiki 名古屋市立大学, 医学(系)研究科(研究院), 研究員 (60444965)
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| Co-Investigator(Kenkyū-buntansha) |
KOHRI Kenjiro 名古屋市立大学, その他部局, 学長 (30122047)
HAYASHI Yutaro 名古屋市立大学, 大学院医学研究科, 准教授 (40238134)
KOJIMA Yoshiyuki 福島県立医科大学, 医学部, 教授 (60305539)
KAMISAWA Hideyuki 名古屋市立大学, 大学院医学研究科, 研究員 (00551277)
MIZUNO Kentaro 名古屋市立大学, 大学院医学研究科, 講師 (70448710)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | 精巣 / 精子幹細胞 / 精巣腫瘍 / 停留精巣 / 精原幹細胞 |
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| Outline of Final Research Achievements |
In order to analyses comprehensive gene expressions in the testes of cryptorchid model rats and elucidate disease genes associated with testicular cancer, we performed following several experiments. We demonstrated as follows; (1) distribution and expression variations of UTF1, specific marker of spermatogonial stem cells, (2) specific expressions of Kdm5a, histone demethylase, and miR-135a in the testes of cryptorchid rats, (3) expression alterations of UTF1 in human testicular cancer tissues.
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