| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
We found heme oxygenase-1 (HO-1) gene up-regulation in response to ultrasound stimulation in endothelial cells. Data obtained from promoter analysis and microarray analysis suggested that the Nrf2/StRE signal pathway induced by oxidative stress was involved in the up-regulation. Ultrasonic irradiation to rat penis enhanced HO-1 expression in the cavernous tissue. HO-1 have the anti-inflammatory, antioxidant, and vasodilatory activities in addition to proangiogenic and vascular reconstitution activities of endothelial cells. Ultrasound irradiation to penis may be applied clinically for erectile dysfunction therapy.
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