Ultrasound irradiation may have therapeutic effect for erectile dysfunction by up-regulating expression of heme oxygenase-1 gene in endothelial cells.
| Project/Area Number |
24592442
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | University of Toyama |
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Principal Investigator |
WATANABE Akihiko 富山大学, 大学院医学薬学研究部(医学), 助教 (20377253)
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| Co-Investigator(Kenkyū-buntansha) |
MORII Akihiro 富山大学, 大学病院, 診療助手 (20377279)
OGAWA Ryohei 富山大学, 大学院医学薬学研究部(医学), 准教授 (60334736)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | ヘムオキシゲナーゼ-1 / 超音波 / 勃起不全 / 血管内皮細胞 / ヘムオキシゲナーゼ1 |
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| Outline of Final Research Achievements |
We found heme oxygenase-1 (HO-1) gene up-regulation in response to ultrasound stimulation in endothelial cells. Data obtained from promoter analysis and microarray analysis suggested that the Nrf2/StRE signal pathway induced by oxidative stress was involved in the up-regulation. Ultrasonic irradiation to rat penis enhanced HO-1 expression in the cavernous tissue. HO-1 have the anti-inflammatory, antioxidant, and vasodilatory activities in addition to proangiogenic and vascular reconstitution activities of endothelial cells. Ultrasound irradiation to penis may be applied clinically for erectile dysfunction therapy.
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Report
(4 results)
Research Products
(8 results)
