Endocrinological study for individual treatment of polycystic ovary syndrome
| Project/Area Number |
24592472
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
IRAHARA Minoru 徳島大学, ヘルスバイオサイエンス研究部, 教授 (20160070)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUZAKI Toshiya 徳島大学, 大学院ヘルスバイオサイエンス研究部, 准教授 (70294692)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 多嚢胞性卵巣症候群 / PCOS / テストステロン / ホルモン測定系 / 代謝異常 / 生活習慣病 / メトホルミン / インスリン抵抗性 / 排卵誘発 |
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| Outline of Final Research Achievements |
We studied endocrinological findings of PCOS to improve diagnosis efficasy and to select suitable treatment for individual patients. Results are follows. 1) Serum testosterone (T) level was elevated in 44.2% of patients, and seemed useful for the diagnosis in Japanese PCOS if it is measured by resent assay system. 2) As for difference among hormone assay systems, T assay systems were not identical. However, LH, FSH, PRL, estradiol and progesterone assay systems showed high relationships among corresponding assay systems. 3) Obesity, free T, androstenedione and ovarian volume were related to risk factors of metabolic syndrome (MBS) in PCOS. These factors would be useful for classification of subtype preventing MBS. 4) Obese or insulin resistant patients were responders of metformin therapy in PCOS, and suggested for metformin use as optional therapy in ovulation induction. These results would improve diagnosis, classification of subtype and suitable treatment selection in PCOS.
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] The responses of hypothalamic NPY and OBRb mRNA expression to food deprivation develop during the neonatal-prepubertal period and exhibit gender differences in rats.2015
Author(s)
Matsuzaki T, Iwasa T, Tungalagsuvd A, Munkhzaya M, Kawami T, Yamasaki M, Murakami M, Kato T, Kuwahara A, Yasui T, Irahara M.
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Journal Title
Int J Dev Neurosci.
Volume: 41
Issue: 1
Pages: 63-67
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Prenatal exposure to glucocorticoids affects body weight, serum leptin levels, and hypothalamic neuropeptide-Y expression in pre-pubertal female rat offspring.2014
Author(s)
Iwasa T, Matsuzaki T, Munkhzaya M, Tungalagsuvd A, Kawami T, Murakami M, Yamasaki M, Kato T, Kuwahara A, Yasui T, Irahara M.
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Journal Title
Int J Dev Neurosci.
Volume: 36
Issue: 1
Pages: 1-4
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Hypothalamic Kiss1 and RFRP gene expressions are changed by a high dose of lipopolysaccharide in female rats.2014
Author(s)
Iwasa T, Matsuzaki T, Tungalagsuvd A, Munkhzaya M, Kawami T, Niki H, Kato T, Kuwahara A, Uemura H, Yasui T, Irahara M.
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Journal Title
Horm Behav.
Volume: 66(2)
Issue: 2
Pages: 309-316
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The effects of LPS-induced endotoxemia on the expression of adiponectin and its receptors in female rats.2014
Author(s)
Iwasa T, Matsuzaki T, Matsui S, Munkhzaya M, Tungalagsuvd A, Kawami T, Murakami M, Kato T, Kuwahara A, Yasui T, Irahara M.
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Journal Title
Endocr J.
Volume: 61(9)
Pages: 891-900
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Changes in the responsiveness of hypothalamic prokineticin 2 mRNA expression to food deprivation in developing female rats.2014
Author(s)
Iwasa T, Matsuzaki T, Munkhzaya M, Tungalagsuvd A, Kawami T, Murakami M, Yamasaki M, Kato T, Kuwahara A, Yasui T, Irahara M.
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Journal Title
Int J Dev Neurosci.
Volume: 34
Issue: 1
Pages: 76-78
DOI
Related Report
Peer Reviewed
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