The differentiation between disease caused by central lesion and by peripheral lesion

• Project/Area Number: 24592546
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Osaka University
• Principal Investigator: IMAI Takao 大阪大学, 医学(系)研究科(研究院), 講師 (80570663)
• Co-Investigator(Kenkyū-buntansha): NAKAMAE Koji 大阪大学, 大学院情報科学研究科, 教授 (40155809) ; 宇野 敦彦 大阪大学, 医学(系)研究科(研究院), 講師 (10335341)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2014: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
• Keywords: 眼球運動解析 / 半規管 / 末梢性疾患 / 中枢性疾患 / 良性発作性頭位めまい症 / アーノルドキアリ奇形 / 星状細胞腫 / 眼球運動三次元解析 / 異常眼球運動 / 病的眼振 / 緩徐相 / 急速相 / 先天性眼振

Outline of Final Research Achievements

By the analysis of abnormal nystagmus using our three-dimensional eye movement analyzing system developed in this study, we made certain that the abnormal nystagmus rotates around the axis perpendicular to the plane of semicircular canal when the cause of disease is peripheral lesion and that the abnormal nystagmus does not rotate around the axis perpendicular to the plane of semicircular canal when the cause of disease is central lesion. By analyzing the rotational axis of abnormal nystagmus it is possible to distinguish the disease with central lesion from the disease with peripheral lesion.

Research Products

• [Journal Article] Bow-tie眼振を示したアーノルド・キアリ奇形の1例 － 240Hz高速サンプリングVOGシステムを用いた三次元眼球運動解析 － (2015)
  • Author(s): 岩本依子，今井貴夫，奥村朋子，真貝佳代子，堀井新，宇野敦彦，西池季隆，太田有美，増村千佐子，鎌倉武史，滝本泰光，大薗芳之，花田有紀子，猪原秀典
  • Journal Title: Equilibrium Research Volume: 未定
  • NAID: 130005073089
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Gadolinium contrast-enhanced MRI reveals cystic lateral semicircular canal contents (2015)
  • Author(s): KAYOKO HIGASHI-SHINGAI, TAKAO IMAI, YASUMITSU TAKIMOTO, TOMOKO OKUMURA, YUMI OHTA, TETSUO MORIHANA, ATSUHIKO UNO, YOSHIYUKI WATANABE, ARATA HORII, HIDENORI INOHARA
  • Journal Title: Acta Oto-laryngologica Volume: 未定
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 眼振の持続時間 (2015)
  • Author(s): 今井貴夫
  • Journal Title: Equilibrium Research Volume: 74
  • NAID: 130005090984
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 方向交代性眼振と外側半規管型良性発作性頭位めまい症 (2015)
  • Author(s): 今井貴夫
  • Journal Title: 神経眼科 Volume: 32 Pages: 1-8
  • NAID: 130005073796
  • Acknowledgement Compliant
• [Journal Article] Light cupula: the pathophysiological basis of persistent geotropic positional nystagmus (2014)
  • Author(s): Takao Imai, Kazunori Matsuda, Noriaki Takeda, Atsuhiko Uno, Tadashi Kitahara, Arata Horii, Suetaka Nishiike, Hidenori Inohara
  • Journal Title: BMJ Open Volume: 4 Issue: 1 Pages: 1-7
  • DOI: 10.1136/bmjopen-2014-006607
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 5-HT3 receptor expression in the mouse vestibular ganglion (2014)
  • Author(s): Takimoto Y, Ishida Y, Nakamura Y, Kamakura T, Yamada T, Kondo M, Kitahara T, Uno A, Imai T, Horii A, Okazaki S, Nishiike S, Inohara H, Shimada S
  • Journal Title: Brain Res Volume: 1557 Pages: 74-82
  • DOI: 10.1016/j.brainres.2014.02.016
  • Peer Reviewed
• [Journal Article] The effect of visual-vestibulosomatosensory conflict induced by virtual reality on postural stability in humans (2014)
  • Author(s): Nishiike S, Okazaki S, Watanabe H, Akizuki H, Imai T, Uno A, Kitahara T, Horii A, Takeda N, Inohara H
  • Journal Title: J Med Invest Volume: 60 Pages: 236-239
  • NAID: 130004822688
  • Peer Reviewed
• [Journal Article] Functional expression of TRPV1 and TRPA1 in rat vestibular ganglia (2013)
  • Author(s): Kamakura T, Ishida Y, Nakamura Y, Yamada T, Kitahara T, Takimoto Y, Horii A, Uno A, Imai T, Okazaki S, Inohara H, Shimada S
  • Journal Title: Neurosci Lett Volume: 552 Pages: 92-97
  • DOI: 10.1016/j.neulet.2013.07.019
  • Peer Reviewed
• [Journal Article] Changes in endolymphatic hydrops after sac surgery examined by Gd-enhanced MRI (2013)
  • Author(s): Uno A, Imai T, Watanabe Y, Tanaka H, Kitahara T, Horii A, Kamakura T, Takimoto Y, Osaki Y, Nishiike S, Inohara H
  • Journal Title: Acta Otolaryngol Volume: 133 Issue: 9 Pages: 924-929
  • DOI: 10.3109/00016489.2013.795290
  • Peer Reviewed
• [Journal Article] Pseudo-anterior canalolithiasis (2013)
  • Author(s): Imai T, Masumura C, Takeda N, Kitahara T, Uno A, Horii A, Nishiike S, Ohta Y, Shingai-Higashi K, Morihana T, Okazaki S, Kamakura T, Takimoto Y, Inohara H
  • Journal Title: Acta Otolaryngol Volume: 133 Issue: 6 Pages: 594-599
  • DOI: 10.3109/00016489.2012.763180
  • Peer Reviewed
• [Journal Article] Long-term results of endolymphatic sac drainage with local steroids for intractable Meniere's disease. (2013)
  • Author(s): Kitahara T, Fukushima M, Uno A, Imai T, Ohta Y, Morihana T, Kamakura T, Horii A, Inohara H
  • Journal Title: Auris Nasus Larynx Volume: なし
  • Peer Reviewed
• [Journal Article] Effects of repeated optic flow stimulation on gait termination in humans. (2013)
  • Author(s): Okazaki S, Nishiike S, Watanabe H, Imai T, Uno A, Kitahara T, Horii A, Kamakura T, Takimoto Y, Takeda N, Inohara H
  • Journal Title: Acta Otolaryngologica Volume: 133 Issue: 3 Pages: 246-252
  • DOI: 10.3109/00016489.2012.740163
  • Peer Reviewed
• [Journal Article] Psychological condition in patients with an acoustic tumor (2013)
  • Author(s): Hio S, Kitahara T, Uno A, Imai T, Horii A, Inohara H
  • Journal Title: Acta Otolaryngologica Volume: 133 Issue: 1 Pages: 42-46
  • DOI: 10.3109/00016489.2012.709322
  • Peer Reviewed
• [Journal Article] Imai T, Masumura C, Takeda N, Kitahara T, Uno A, Horii A, Nishiike S, Ohta Y, Shingai-Higashi K, Morihana T, Okazaki S, Kamakura T, Takimoto Y, Inohara H (2013)
  • Author(s): Pseudo anterior canalolithiasis
  • Journal Title: Acta Otolaryngologica Volume: なし
• [Journal Article] Implication of substance P neuronal system in the amygdala as a possible mechanism for hypergravity-induced motion sickness. (2012)
  • Author(s): Horii A, Nakagawa A, Uno A, Kitahara T, Imai T, Nishiike S, Takeda N, Inohara H
  • Journal Title: Brain Research Volume: 1436 Pages: 91-98
  • DOI: 10.1016/j.brainres.2011.11.047
• [Journal Article] Changes in beta-2 adrenergic receptor and AMP-activated protein kinase alpha-2 subunit in the rat vestibular nerve after labyrinthectomy (2012)
  • Author(s): Kitahara T, Horii A, Uno A, Imai T, Okazaki S, Kamakura T, Takimoto Y, Inohara H
  • Journal Title: Neuroscience Research Volume: 72 Issue: 3 Pages: 221-226
  • DOI: 10.1016/j.neures.2011.11.007
  • Peer Reviewed
• [Journal Article] Benign paroxysmal positional vertigo showing sequential translations of four types of nystagmus. (2012)
  • Author(s): Imai T, Takeda N, Uno A, Horii A, Kitahara T, Nishiike S, Higashi-Shingai K, Inohara H
  • Journal Title: Auris Nasus Larynx Volume: 39 Issue: 5 Pages: 544-548
  • DOI: 10.1016/j.anl.2011.10.007
  • Peer Reviewed
• [Presentation] New scoring system of interview for diagnosis of benign paroxysmal positional vertigo (2015)
  • Author(s): Takao Imai, Kayoko Higashi-Shingai, Yasumitsu Takimoto, Chisako Masumura, Atsuhiko Uno, Suetaka Nishiike, Yumi Ohta, Tetsuo Morihana, Takashi Sato, Takefumi Kamakura, Tomoko Okumura, Yoriko Iwamoto, Yukiko Hanada, Yoshiyuki Ozono, Ryusuke Imai, Hidenori Inohara
  • Organizer: 30th Politzer Society Meeting
  • Place of Presentation: 朱鷺メッセ
  • Year and Date: 2015-06-30 – 2015-07-03
• [Presentation] Light cupula the pathophysiological basis of persistent geotropic positional nystagmus (2015)
  • Author(s): Takao Imai
  • Organizer: 2015 International congress of korean society of otorhinolaryngology-head & neck surgery
  • Place of Presentation: Grand Hilton Hotel, Seoul, Korea
  • Year and Date: 2015-04-24 – 2015-04-26
  • Invited
• [Presentation] Pseudo-anterior canalolithiasis (2014)
  • Author(s): Takao Imai
  • Organizer: Joint Meeting of Japan Society for Equilibrium Research and The Korean Balance Society
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-11-07
  • Invited
• [Presentation] パネルディスカッション「外側半規管型良性発作性頭位めまい症 (2014)
  • Author(s): 今井貴夫
  • Organizer: 第73回日本めまい平衡医学会総会・学術講演会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-11-06
  • Invited
• [Presentation] 良性発作性頭位めまい症の診断のための問診スコアリング (2014)
  • Author(s): 今井貴夫・真貝佳代子・滝本泰光・大薗芳之太田有美・森鼻哲生・猪原秀典
  • Organizer: 第24回日本耳科学会総会・学術講演会
  • Place of Presentation: 朱鷺メッセ
  • Year and Date: 2014-10-16
• [Presentation] Failure of liberatory maneuvers in anterior canal type of benign paroxysmal positional vertigo (2013)
  • Author(s): Takao Imai, Tadashi Kitahara, Noriaki Takeda, Arata Horii, Atsuhiko Uno, Hidenori Inohara
  • Organizer: 29th Politzer Society Meeting
  • Place of Presentation: Antalya, Turkey
• [Presentation] Diagnosis of affected semicircular canal in patients with BPPV using three-dimensional analysis of positional nystagmus (2013)
  • Author(s): Takao Imai, Noriaki Takeda, Hidenori Inohara
  • Organizer: 20th IFOS World Congress
  • Place of Presentation: Seoul, Korea
• [Presentation] 聴衆参加型パネルディスカッション Decision Making - その時、あなたはどうする？ - めまい (2013)
  • Author(s): 今井貴夫
  • Organizer: 第75回耳鼻臨床学会
  • Place of Presentation: 神戸、兵庫
• [Presentation] 減衰型、持続型の方向交代性下向性眼振の鑑別 (2013)
  • Author(s): 今井貴夫、岡崎鈴代、武田憲昭、北原糺、宇野敦彦、堀井新、太田有美、森鼻哲生、増村千佐子、真貝佳代子、猪原秀典
  • Organizer: 第23回日本耳科学会総会・学術講演会
  • Place of Presentation: 宮崎、宮崎
• [Presentation] Endolymphatic hydrops detected by inner ear Gd-enhanced MRI, ECochG or glycerol test. (2012)
  • Author(s): Uno A, Horii A, Imai T, Kitahara T, Kamakura T,Takimoto Y, Osaki Y, Watanabe Y, Tanaka H, Inohara H
  • Organizer: 27th Barany Society Meeting
  • Place of Presentation: Uppsala, Sweden
• [Presentation] Functional expression of TRPA1 and TRPV1 in rat vestibular ganglia. (2012)
  • Author(s): Kamakura T, Ishida Y, Nakamura Y, Yamada T, Kitahara T, Takimoto Y, Horii A, Uno A, Imai T, Okazaki S, Inohara H, Shimada S
  • Organizer: 27th Barany Society Meeting
  • Place of Presentation: Uppsala, Sweden
• [Presentation] Adrenergic signaling in the rat eighth nerve after labyrinthectomy. (2012)
  • Author(s): Kitahara T, Fukushima S, Michiba T, Ozono Y, Imai R, Horii A, Uno A, Imai T, Kamakura T, Takimoto Y, Inohara H
  • Organizer: 27th Barany Society Meeting
  • Place of Presentation: Uppsala, Sweden
• [Presentation] Differential diagnosi of pseudo-anterior canal type of benign paroxysmal positional nystagmus originating in posterior canal from true anterior canal type of benign paroxysmal positional nystagmus. (2012)
  • Author(s): Imai T, Masumura C, Takeda N, Kitahara T, Uno A, Horii A, Nishiike S, Shingai-Higashi K, Okazaki S, Kamakura T, Takimoto Y, Inohara H
  • Organizer: 27th Barany Society Meeting
  • Place of Presentation: Uppsala, Sweden
• [Presentation] Analyzing congenital nystagmus using high-speed video-oculography with 240Hz sampling rate. (2012)
  • Author(s): Masumura C, Imai T, Uno A, Inohara H
  • Organizer: 27th Barany Society Meeting
  • Place of Presentation: Uppsala, Sweden
• [Presentation] Three-dimensional vestibulo-ocular reflex in eccentric rotation can evaluate the otolith function in humans. (2012)
  • Author(s): Takimoto Y, Imai T, Takeda N, Uno A, Horii A, Kitahara T, Nishiike S, Koizuka I, Shingai K, Masumura C, Okazaki S, Kamakura T, Maekawa C, Inohara H
  • Organizer: 27th Barany Society Meeting
  • Place of Presentation: Uppsala, Sweden
• [Presentation] Postural habituations to repeated optic flow stimulation in gait termination. (2012)
  • Author(s): Okazaki S, Nishiike S, Watanabe H, Imai T, Uno A, Kitahara T, Horii A, Takeda N, Inohara H
  • Organizer: 27th Barany Society Meeting
  • Place of Presentation: Uppsala, Sweden
• [Presentation] Simulation of positioning nystagmus during the Dix-Hallpike maneuver through a balance control and eye movement simulator using accelerometer and gyroscope sensor data. (2012)
  • Author(s): Midoh Y, Hiraki K, Imai T, Uno A, Inohara H, Nakamae K
  • Organizer: 27th Barany Society Meeting
  • Place of Presentation: Uppsala, Sweden
• [Presentation] Translation from continuous horizontal nystagmus to geotropic positional nystagmus. (2012)
  • Author(s): Iwamoto Y, Imai T, Takeda N, Uno A, Horii A, Kitahara T, Nishiike S, Higashi-Shingai K, Masumura C, Okazaki S, Kamakura T, Takimoto Y, Inohara H
  • Organizer: 27th Barany Society Meeting
  • Place of Presentation: Uppsala, Sweden