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Investigation of the mechanisms of intraocular pressure regulation (elevation) by estrogen-receptor

Research Project

Project/Area Number 24592621
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionUniversity of Yamanashi

Principal Investigator

MABUCHI Fumihiko  山梨大学, 総合研究部, 講師 (20322125)

Co-Investigator(Kenkyū-buntansha) AIHARA Makoto  東京医科歯科大学, その他部局等, 教授 (80222462)
SAKURADA Yoichi  山梨大学, 総合研究部, 助教 (90456476)
KASHIWAGI Kenji  山梨大学, 総合研究部, 准教授 (30194723)
IIJIMA Hiroyuki  山梨大学, 総合研究部, 教授 (80114362)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsエストロゲン受容体 / ESR2 / ESR2ノックアウトマウス / 眼圧 / 原発開放隅角緑内障 / POAG / ESR1 / ESR1ノックアウトマウス
Outline of Final Research Achievements

We previously investigated whether the estrogen receptor beta (ESR2) gene single nucleotide polymorphisms (SNPs) were associated with primary open-angle glaucoma (POAG), and our findings demonstrated a higher frequency of the ESR2 gene SNPs in female patients with POAG in comparison to control subjects, and the maximum intraocular pressure (IOP) in female patients with the risk allele was significantly higher than that in female patients without the risk allele. To elucidate the molecular mechanisms of IOP regulation (elevation) and evaluate the possibility of ESR2 knockout mice as a POAG model, the IOP and optic nerve damage of ESR2 knockout mice were investigated. There was no statistically significant IOP difference (P>0.05) between ESR2 knockout and control (wild type) mice. The retinal thickness and retinal ganglion cells of ESR2 knockout and control mice has been measured and will be counted to evaluate the optic nerve damage.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (25 results)

All 2015 2014 2012 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Acknowledgement Compliant: 1 results) Presentation (15 results) Book (1 results) Remarks (6 results)

  • [Journal Article] Involvement of genetic variants associated with primary open-angle glaucoma in pathogenic mechanisms and family history of glaucoma2015

    • Author(s)
      Mabuchi F, Sakurada Y, Kashiwagi K, Yamagata Z, Iijima H, Tsukahara S
    • Journal Title

      Am J Ophthalmol

      Volume: 159 Issue: 3 Pages: 437-444.e2

    • DOI

      10.1016/j.ajo.2014.11.023

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Association between genetic variants associated with vertical cup-to-disc ratio and phenotypic features of primary open-angle glaucoma.2012

    • Author(s)
      Fumihiko Mabuchi
    • Journal Title

      Ophthalmology

      Volume: 119(9) Issue: 9 Pages: 1819-25

    • DOI

      10.1016/j.ophtha.2012.02.044

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Risk factors for anxiety and depression in patients with glaucoma2012

    • Author(s)
      Mabuchi F, Yoshimura K, Kashiwagi K, Yamagata Z, Kanba S, Iijima H, Tsukahara S
    • Journal Title

      Br J Ophthalmol

      Volume: 96 Issue: 6 Pages: 821-825

    • DOI

      10.1136/bjophthalmol-2011-300910

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] CAV1/CAV2 遺伝子多型と原発開放隅角緑内障の表現型と の関連について2014

    • Author(s)
      間渕文彦 櫻田庸一 米山征吾 柏木賢治 山縣然太朗 飯島裕幸
    • Organizer
      第68回日本臨床眼科学会
    • Place of Presentation
      神戸 ポートピアホテル・神戸国際展示場(兵庫県・神戸市)
    • Year and Date
      2014-11-13 – 2014-11-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] Association between common variant near CAV1 and CAV2 genes and phenotypic features of primary open-angle glaucoma2014

    • Author(s)
      Fumihiko Mabuchi, Yoichi Sakurada, Seigo Yoneyama, Kenji Kashiwagi, Zentaro Yamagata, Hiroyuki Iijima
    • Organizer
      American Society of Human Genetics Annual Meeting
    • Place of Presentation
      San Diego(USA)
    • Year and Date
      2014-10-18 – 2014-10-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] Association between GAS7 genetic variant and primary open-angle glaucoma in the Japanese population2014

    • Author(s)
      Fumihiko Mabuchi, Yoichi Sakurada, Seigo Yoneyama, Kenji Kashiwagi, Zentaro Yamagata, Hiroyuki Iijima
    • Organizer
      11th European Glaucoma Society Congress
    • Place of Presentation
      Nice(France)
    • Year and Date
      2014-06-07 – 2014-06-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Association between GAS7 genetic variant and primary open-angle glaucoma in the Japanese population2014

    • Author(s)
      Fumihiko Mabuchi, Yoichi Sakurada, Seigo Yoneyama, Kenji Kashiwagi, Zentaro Yamagata, Hiroyuki Iijima
    • Organizer
      The Association for Research in Vision and Ophthalmology
    • Place of Presentation
      Orlando(USA)
    • Year and Date
      2014-05-04 – 2014-05-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] GAS7 遺伝子多型と日本人原発開放隅角緑内障の関連につ いて2014

    • Author(s)
      間渕文彦 櫻田庸一 米山征吾 柏木賢治 山縣然太朗 飯島裕幸
    • Organizer
      第118回日本眼科学会
    • Place of Presentation
      東京国際フォーラム(東京都・千代田区丸の内)
    • Year and Date
      2014-04-02 – 2014-04-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 正常眼圧緑内障感受性遺伝子と緑内障家族歴の関連について

    • Author(s)
      間渕文彦, 櫻田庸一, 柏木賢治, 山縣然太朗, 飯島裕幸, 塚原重雄
    • Organizer
      第117回日本眼科学会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Related Report
      2013 Research-status Report
  • [Presentation] Association between primary open-angle glaucoma and genetic variants associated with normal tension glaucoma

    • Author(s)
      Fumihiko Mabuchi, Yoichi Sakurada, Kenji Kashiwagi, Zentaro Yamagata, Hiroyuki Iijima, Shigeo Tsukahara
    • Organizer
      Association for Research in Vision and Ophthalmology (ARVO)
    • Place of Presentation
      Washington State Convention Center (Seattle)
    • Related Report
      2013 Research-status Report
  • [Presentation] Association between primary open-angle glaucoma and genetic variants associated with optic nerve vulnerability

    • Author(s)
      Fumihiko Mabuchi, Yoichi Sakurada, Kenji Kashiwagi, Zentaro Yamagata, Hiroyuki Iijima, Shigeo Tsukahara
    • Organizer
      World Glaucoma Congress
    • Place of Presentation
      Vancouver Convention Center (Vancouver)
    • Related Report
      2013 Research-status Report
  • [Presentation] Association between estrogen receptor and intraocular pressure in mice

    • Author(s)
      Fumihiko Mabuchi, Reiko Yamagishi, Kenji Kashiwagi, Makoto Aihara
    • Organizer
      American Society of Human Genetics (ASHG)
    • Place of Presentation
      Boston Convention and Exhibition Center (Boston)
    • Related Report
      2013 Research-status Report
  • [Presentation] 正常眼圧緑内障感受性遺伝子多型と原発開放隅角緑内障発症の関係について

    • Author(s)
      間渕文彦, 櫻田庸一, 柏木賢治, 山縣然太朗, 飯島裕幸, 塚原重雄
    • Organizer
      第67回日本臨床眼科学会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2013 Research-status Report
  • [Presentation] Association between estrogen receptor beta gene polymorphisms and intraocular pressure elevation in women

    • Author(s)
      Mabuchi F, Sakurada Y, Kashiwagi K, Yamagata Z, Iijima H, Tsukahara S
    • Organizer
      Association for Research in Vision and OPhthalmology (ARVO)
    • Place of Presentation
      Broward County Convention Center (Fort Lauderdale)
    • Related Report
      2012 Research-status Report
  • [Presentation] Association between glaucoma heritability and genetic variants associated with normal tension glaucoma

    • Author(s)
      Mabuchi F, Sakurada Y, Kashiwagi K, Yamagata Z, Iijima H, Tsukahara S
    • Organizer
      European Glaucoma Society Congress
    • Place of Presentation
      Tivoli Congress Center (Copenhagen)
    • Related Report
      2012 Research-status Report
  • [Presentation] Estrogen receptor beta genetic variants are associated with intraocular pressure elevation in women

    • Author(s)
      Mabuchi F, Sakurada Y, Kashiwagi K, Yamagata Z, Iijima H, Tsukahara S
    • Organizer
      American Society of Human Genetics
    • Place of Presentation
      Moscone Center (San Francisco)
    • Related Report
      2012 Research-status Report
  • [Presentation] Estrogen receptor beta遺伝子多型と眼圧の関連について

    • Author(s)
      間渕文彦, 櫻田庸一, 柏木賢治, 山縣然太朗, 飯島裕幸, 塚原重雄
    • Organizer
      第116回日本眼科学会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Related Report
      2012 Research-status Report
  • [Presentation] Estrogen receptor beta遺伝子多型と眼圧の関連について

    • Author(s)
      間渕文彦, 櫻田庸一, 柏木賢治, 山縣然太朗, 飯島裕幸, 塚原重雄
    • Organizer
      第66回日本臨床眼科学会
    • Place of Presentation
      京都国際会議場(京都)
    • Related Report
      2012 Research-status Report
  • [Book] Glaucoma 2nd Edition2014

    • Author(s)
      Tarek M. Shaarawy, Mark B. Sherwood, Roger A. Hitchings, Jonathan G. Crowston
    • Total Pages
      1
    • Publisher
      Elsevier
    • Related Report
      2014 Annual Research Report
  • [Remarks] 山梨大学研究者総覧

    • URL

      http://erdb.yamanashi.ac.jp/rdb/A_DispInfo.Scholar?ID=11CB59E63296DFFE

    • Related Report
      2014 Annual Research Report
  • [Remarks] 山梨大学 技術・研究情報

    • URL

      http://sangaku.yamanashi.ac.jp/SearchResearcher/contents/11CB59E63296DFFE.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 山梨大学 研究者総覧

    • URL

      http://erdb.yamanashi.ac.jp/rdb/A_DispInfo.Scholar?ID=11CB59E63296DFFE

    • Related Report
      2013 Research-status Report
  • [Remarks] 山梨大学 技術・研究情報

    • URL

      http://sangaku.yamanashi.ac.jp/SearchResearcher/contents/11CB59E63296DFFE.html

    • Related Report
      2013 Research-status Report
  • [Remarks] 山梨大学 研究者総覧

    • URL

      http://erdb.yamanashi.ac.jp/rdb/A_DispInfo.Scholar?ID=11CB59E63296DFFE

    • Related Report
      2012 Research-status Report
  • [Remarks] 山梨大学 技術・研究情報

    • URL

      http://sangaku.yamanashi.ac.jp/SearchResearcher/contents/11CB59E63296DFFE.html

    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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