| Project/Area Number |
24592637
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Nara Medical University |
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Principal Investigator |
OGATA NAHOKO 奈良県立医科大学, 医学部, 教授 (60204062)
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| Co-Investigator(Kenkyū-buntansha) |
KURUMATANI Norio 奈良県立医科大学, 医学部, 教授 (10124877)
UEDA Tetsuo 奈良県立医科大学, 医学部, 講師 (00364068)
NISHI Tomo 奈良県立医科大学, 医学部, 助教 (70571214)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 視機能 / 加齢黄斑変性 / 認知症 / 白内障 / コホート研究 / 高齢者 / 疫学調査 / 高齢者の視機能 / 疫学研究 / 認知機能 |
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| Outline of Final Research Achievements |
We conducted ophthalmological examinations in elderly Japanese named Fujiwara-Kyo Eye study in which attended 2868 volunteers (mean age was 76.3±4.9, including 1513 men). The mean best corrected visual acuity (BCVA) was 0.048 ± 0.26 logMAR units and 6.6% was classified as being visually impaired (>0.5 logMAR units). In addition, 21.5% of eyes had undergone cataract surgery. The mean Mini-Mental State Examination (MMSE) score was 27.3±2.3 and 5.7% of the subjects was defined as being cognitively impaired.
The mean plasma concentration of PEDF (pigment epithelium-derived factor) (10.2±3.14μg/ml ) in subjects with age-related macular degeneration (AMD) was significantly higher than that of controls (8.23±1.88μg/ml, p＜0.01). These results indicated that PEDF effects on the pathogenesis of AMD.
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