Visual Acuity and effects of general factor and pigment epithelium-derived factor on eye diseases in Japanese Elderly
| Project/Area Number |
24592637
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Nara Medical University |
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Principal Investigator |
OGATA NAHOKO 奈良県立医科大学, 医学部, 教授 (60204062)
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| Co-Investigator(Kenkyū-buntansha) |
KURUMATANI Norio 奈良県立医科大学, 医学部, 教授 (10124877)
UEDA Tetsuo 奈良県立医科大学, 医学部, 講師 (00364068)
NISHI Tomo 奈良県立医科大学, 医学部, 助教 (70571214)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 視機能 / 加齢黄斑変性 / 認知症 / 白内障 / コホート研究 / 高齢者 / 疫学調査 / 高齢者の視機能 / 疫学研究 / 認知機能 |
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| Outline of Final Research Achievements |
We conducted ophthalmological examinations in elderly Japanese named Fujiwara-Kyo Eye study in which attended 2868 volunteers (mean age was 76.3±4.9, including 1513 men). The mean best corrected visual acuity (BCVA) was 0.048 ± 0.26 logMAR units and 6.6% was classified as being visually impaired (>0.5 logMAR units). In addition, 21.5% of eyes had undergone cataract surgery. The mean Mini-Mental State Examination (MMSE) score was 27.3±2.3 and 5.7% of the subjects was defined as being cognitively impaired.
The mean plasma concentration of PEDF (pigment epithelium-derived factor) (10.2±3.14μg/ml ) in subjects with age-related macular degeneration (AMD) was significantly higher than that of controls (8.23±1.88μg/ml, p＜0.01). These results indicated that PEDF effects on the pathogenesis of AMD.
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Report
(4 results)
Research Products
(92 results)
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[Journal Article] Short-term influence of cataract surgery on circadian biological rhythm and related health outcomes (CLOCK-IOL trial): study protocol for a randomized controlled trial2014
Author(s)
Saeki K, Obayashi K, Nishi T, Miyata K, Maruoka S, Ueda T, Okamoto M, Hasegawa T, Matsuura T, Tone N, Ogata N, Kurumatani N
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Journal Title
Trials
Volume: 29
Issue: 1
Pages: 514-522
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Combined Addition of Interleukin-6 and Dexamethasone Prevented Reg Protein-induced ß-Cell Apoptosis through Activation of HGF Gene TranscriptionView session detail2014
Author(s)
Shin Takasawa, Kei Nakagawa, Kouji Nata, Akiyo Yamauchi, Asako Hironaka, Hiroyo Ota, Sumiyo Tsuchida, Maiko Takeda, Takanori Fujimura, Hiroki Tsujinaka, Michiaki Unno, Hiroshi Okamoto
Organizer
American Diabetes Association 2014
Place of Presentation
サンフランシスコ（アメリカ）
Year and Date
2014-06-13 – 2014-06-17
Related Report
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[Presentation] Exposure to evening light,sleep initiation and obesity in elderly individuals:a cross-sectional study in the HEIJO-KYO-cohort2014
Author(s)
Kenji Obayashi, Keigo Saeki, Nobuhiro Tone, Tomo Nishi, Kimie Miyata, Naoto Otaki, Maiko Kitagawa, Takanori Noguchi, Naoko Mochida, Norio Kurumatani
Organizer
SLEEP 2014
Place of Presentation
ミネアポリスコンベンションセンター（ミネソタ州・アメリカ）
Year and Date
2014-05-31 – 2014-06-04
Related Report
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[Presentation] 高齢者の眼
Author(s)
緒方奈保子
Organizer
第119回京都眼科学会
Place of Presentation
京都
Related Report
Invited
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