Osx regulates osteoblast differentiation through association with coactivators
| Project/Area Number |
24592784
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Tsurumi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
AKIRA Nifuji 鶴見大学, 歯学部, 教授 (00240747)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 骨芽細胞 / 転写因子 / 細胞分化 / 分化 |
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| Outline of Final Research Achievements |
Osteoblast differentiation is a multistep pathway in which multipotential mesenchymal cells differentiate into osteoblasts. The transcription factor Osterix (Osx) regulates osteoblast differentiation and bone-specific gene expression. However, Osx expression is detected not only in osteogenic tissue but also in chondrogenic tissues, suggesting the presence of molecules required to control osteogenesis by Osx. In the current studies, we have analyzed possible Osx partner molecules Osx coactivator 1 (OSC1) and Osx coactivator 2 (OSC2). The results suggest that the two molecules associate with Osx as a coactivator during osteoblast differentiation. Expression of OSC1 is induced during osteoblast differentiation in vitro. OSC1 and OSC2 directly interact with Osx and promote Osx-dependent transcriptional activity, suggesting that OSCs act as a transcriptional coactivator for Osx. Our results provide new insights into a transcriptional regulation of osteoblast differentiation by Osx.
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Report
(4 results)
Research Products
(30 results)
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[Presentation] Three Histone 3 Lysine 9 Methyltransferases, G9a, GLP, And SETDB1, Are Expresssed During Mouse Tooth Development2013
Author(s)
Kamiunten T, Shimada A, Ideno H, Nakashima K, Nakamura Y, Nifuji A.
Organizer
2nd Joint Meeting of the International Bone and Mineral Society and The Japanese Society for Bone and Mineral Research
Place of Presentation
Kobe International Conference Center and Kobe Portopia Hotel,
Related Report
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[Presentation] enocytes Regulate Cell Survical of Osteoblasts In Vitro2013
Author(s)
Wada S, Shimada A, Ideno H, Nakamura Y, Nakashima K, Nifuji A.
Organizer
2nd Joint Meeting of the International Bone and Mineral Society and The Japanese Society for Bone and Mineral Research
Place of Presentation
Kobe International Conference Center and Kobe Portopia Hotel,
Related Report
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