| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
microRNAs (miRNAs), function as important regulators of a wide range of cellular processes by modulating gene expression. The functions and relate pathway of miRNAs have been extensively studied, but additional roles in various cellular processes remain to be understood.
We investigated the biological importance of individual miRNA to target-mRNA interactions by comparing miRNA-mRNA expression profiles in two normal human salivary gland cell lines named NS-SV-AC (AC) and NS-SV-DC (DC). Our results supports a miRNA can regulate several transcripts and the target-mRNAs are often context specific.
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